NCT03428672Unknown不适用
Collection of Bone Specimens for Quantitative Analysis of Global Proteome and Iron Content Detection
Second Affiliated Hospital of Soochow University1 个研究点 分布在 1 个国家目标入组 100 人开始时间: 2018年4月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- the iron content in human bone samples
研究概览
简要总结
RATIONALE: Collecting and storing bone samples from patients with osteoporotic and nonosteoporotic fracture to quantitatively analyze the differentially expressed proteins to further explain the relationship between bone iron content and bone mineral density (BMD).
PURPOSE: This research study is looking at changes of iron content and differentially expressed proteins in bone samples from patients with osteoporotic and nonosteoporotic.
fracture.
详细描述
OBJECTIVES:
- Establish the iron content in bone specimen in patients with hip fracture.
- Explore the correlation of BMD and differentially expressed proteins.
OUTLINE:
- Collect human bone specimens from patients with osteoporotic and nonosteoporotic Fracture.
- Provide a repository for storage of tissue and make these specimens available for approved projects by laboratory-based investigators.
- Collect clinical data on these patients including bone mineral density.
- To examine the bone iron content using ICP/MS.
- Investigate the differentially expressed proteins through quantitative analysing the global proteome of osteoporotic and nonosteoporotic fracture bone specimens.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 55 Years 至 90 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Ages Eligible for Study: 55-90 Years
- •Genders Eligible for Study: Woman
- •Accepts Healthy Volunteers: NO
- •Study Population: Female patients with hip fracture.
排除标准
- •Malignancy or benign ovarian cysts
- •Known chronic or systemic diseases
- •Hormone therapy in the previous 3 months
- •Bone metabolism and drug therapy
结局指标
主要结局
the iron content in human bone samples
时间窗: 3 month
Bone samples were preprocess and decomposed by microwave.Icp-ms is used for quantitative detection of samples.
次要结局
- The value of bone mineral density(one week)
- Quantitative Analysis of Global Proteome in bone samples(5 month)
研究者
You-Jia Xu
Director
Second Affiliated Hospital of Soochow University
研究点 (1)
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