The "Motoric Cognitive Risk" Syndrome in the Canadian Population

Active, not recruiting

• Conditions: Dementia; Cognition Disorders in Old Age; Cardiovascular Diseases
• Interventions: Other: Summarize of participants' characteristics using means and standard deviations or frequencies and percentages

• Registration Number: NCT03679026
• Lead Sponsor: Jewish General Hospital

Brief Summary

Cognition and locomotion are two human abilities controlled by the brain. Their decline is highly prevalent with aging, and is greater than the simple sum of their respective prevalence, suggesting a complex age-related interplay between cognition and locomotion. Recently, a systematic review and meta-analysis has provided evidence that poor gait performance predicts dementia and, in particular, has demonstrated that "motoric cognitive risk" (MCR) syndrome, which has been described in cognitively healthy individuals and combines subjective cognitive complaint with objective slow gait speed, is a pre-dementia syndrome. The uniqueness of "motoric cognitive risk" (MCR)syndrome is that it does not rely on a complex evaluation or laboratory investigations. Thus, it is easy to apply in population-based settings. The overall objective of the proposal is to examine the epidemiology of the newly reported "motoric cognitive risk" (MCR) syndrome, in the Quebec population using the database of the NuAge study.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-08-22
• Study First Submitted: 2018-08-21
• Study First Submitted QC: 2018-09-18
• Study First Posted: 2018-09-20
• Primary Completion: 2021-08-21
• Status Verified: 2024-04
• Last Update Submitted: 2024-04-04
• Last Update Posted: 2024-04-05
• Study Completion: 2024-12-21

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 1461

Inclusion Criteria

• Individuals eligible for this study will be participants of the NuAge study

Exclusion Criteria

• Individuals not eligible for the NuAge study
• dementia
• mobility disability
• no information about cognitive complaint
• no measure of walking speed

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
CVRF	Summarize of participants' characteristics using means and standard deviations or frequencies and percentages	individuals with cardio-vascular risk factors and diseases
WCVRF	Summarize of participants' characteristics using means and standard deviations or frequencies and percentages	individuals without cardio-vascular risk factors and diseases

Primary Outcome Measures

Name	Time	Method
Cardio-vascular risk factors and diseases assessed using reported health condition	1 day	medical history

Secondary Outcome Measures

Name	Time	Method
Cardio-vascular risk factors and diseases assessed using physical examination: BMI	1 day	body mass index
Cardio-vascular risk factors and diseases assessed using physical examination: HW ratio	1 day	hip-waist ratio
Disability and functional limitations	12 months	History of falls during the past 12 months
Cognitive performance	1 day	Choice Reaction Time Test (CRT)
physical and mental health	1 day	Self-perception of health and mental health
Physical performance	1 day	Physical Activity Scale for the Elderly, scored between 0 and 400, low scores indicate sarcopenia
Cardio-vascular risk factors and diseases assessed using physical examination: blood pressure	1 day	(value of systolic, diastolic when participants are seated in an upright position in a chair)
Depression	1 day	measured by the 10 items of the Center for Epidemiological Studies Short Depression Scale. Participants with a score of 10 or greater are considered as depressed. Scores with more than 2 missing items will be excluded.

Trial Locations

Locations (1)

Jewish General Hospital; 🇨🇦 Montréal, Quebec, Canada