Estimation of the Placental Volume by 3D Ultrasound at 12, 16 and 22 Weeks : Relation With Growth Factors and D-Dimers
- Conditions
- Placenta Vascular Malformation
- Interventions
- Other: blood sample
- Registration Number
- NCT00767182
- Brief Summary
Pregnancy complications called PVP are mainly responsible for perinatal mortality. In these cases, the placenta is smaller and often the centre of thrombotic lesions. The estimation of the placenta volume by 3D ultrasound coupled with growth factors and D-Dimers measures could improve the understanding of these pathologies to optimize their detection.
- Detailed Description
Pregnancy complications called Placental Vascular Pathologies (PVP) are mainly responsible for perinatal mortality. In these cases, the placenta is smaller and often the centre of thrombotic lesions. The estimation of the placenta volume by 3D ultrasound coupled with growth factors and D-Dimers measures could improve the understanding of these pathologies to optimize their detection. Thus, the identification of predictive factors of the risk of occurrence or recurrence of PVP could allow us to propose a monitoring of patients at risk, to anticipate corticoids administration for the foetuses pulmonary maturation and perhaps later to adapt anti hypertensive and antithrombotic therapeutics.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 40
- previous history of one or more PVC episodes : preeclampsia, HELLPs, retroplacental hematoma, vascular IUGR<10th percentile, recurrence miscarriage >2, unexplained IUFD or IUFD after abruption placentae, eclampsia.
- coming for a 12 weeks ultrasound
- Multiple pregnancy
- past history of in utero fetal death due to congenital malformations, rhesus incompatibility or an infection
- previous history of IUGR which etiology was a chromosomal, genic or infectious anomaly
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Pregnant patients with VPP antecedent blood sample Pregnancy women consulting for an scan during their 12th week of amenorrhea at the University Hospital of Saint Etienne will be studied in this clinical trial. They have an history of VPP (Vascular Placental Pathology). They will have to give a blood sample.
- Primary Outcome Measures
Name Time Method placental volume by 3D ultrasound and D-Dimers rate Week 12
- Secondary Outcome Measures
Name Time Method Occurrence or recurrence of PVP Week 22 placental volume by 3D ultrasound and D-Dimers rate Week 22 EPCRs rate measurements Week 22
Trial Locations
- Locations (1)
Service de Gynécologie Obstétrique - CHU Saint-Etienne
🇫🇷Saint-Etienne, France