Comparison the effects of silymarin and N-acetylcysteine on improvement of, Hepatic and renal Abnormalities in Patients with SeverePreeclampsia in post-partum

Phase 2

Recruiting

Conditions: Preeclampcia.
O14.1
Severe pre-eclampsia

Registration Number: IRCT20191231045965N1

Lead Sponsor: Shahre-kord University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Female

Target Recruitment: 60

Inclusion Criteria

Maternal age is between 20 and 30 years.
mothers BMI is between 20 and 24.
Gestational age at termination of pregnancy is between 35 and 42 weeks.
The patient's blood pressure should be greater than 140/90 mmHg before termination of pregnancy.
Proteinuria, in urine random sample before pregnancy termination.
Lack of history of hypertension, diabetes, kidney disease, collagen vascular disease and other cardiovascular diseases.
The mother is nulipar and has no previous abortion or pregnancy.
No history of smoking or alcohol in the mother.
Pregnancy is single and not molar.
Indication of termination of pregnancy in a patient with severe preeclampsia.
The patient has complete consent to participate in the study and has signed the consent form.
No incidence of eclampsia prior to inclusion.

Exclusion Criteria

Patient dissatisfaction to participate in the study
Patient with eclampsia

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
iver enzymes. Timepoint: 0,12,36 and 60 hours after intervention. Method of measurement: labratoary kit.;Platlet count. Timepoint: 0,12,36 and 60 hours after intervention. Method of measurement: count in mm3.;Proteinuria. Timepoint: 0,12,36 and 60 hours after intervention. Method of measurement: labratoary kit.;Urea. Timepoint: 0,12,36 and 60 hours after intervention. Method of measurement: mg per dl.;Creatinine. Timepoint: 0,12,36 and 60 hours after intervention. Method of measurement: mg per dl.;Blood pressure. Timepoint: q 3 hours in study. Method of measurement: mmHg.

Secondary Outcome Measures