Prevalence of Pathogens in Cerebrospinal Fluid Obtained From Emergency Department Patients

Terminated

• Conditions: Meningoencephalitis; Other Syndromes Requiring Lumbar Puncture in Emergency Department
• Interventions: Other: no intervention

• Registration Number: NCT02207647
• Lead Sponsor: Olive View-UCLA Education & Research Institute

Brief Summary

Of all emergency room patients, persons presenting with encephalitis/meningitis syndrome of a potentially infectious nature are among those of greatest concern. Routine clinical and laboratory evaluation of such patients involves screening for known infectious disease agents, selection of which is nonstandardized. Progress in diagnostic technologies, especially molecular techniques based on genetic characteristics of potential pathogens, has greatly expanded the investigators capacity to evaluate specimens from patients for a much wider range of potential pathogens (bacterial, viral, fungal and parasitic agents). Use of Polymerase Chain Reaction (PCR) technology offers the possibility of identifying causative agents for the approximately 50% of all such presentations which go un-diagnosed. The investigators propose a study involving a collaboration between the EMERGEncy ID NET, a network of 10 geographically diverse university-affiliated urban emergency departments (coordinated by Olive View-UCLA Medical Center) and the Centers for Disease Control and Prevention (CDC), to use these new technologies to address this issue.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-04
• Study First Submitted: 2014-07-31
• Study First Submitted QC: 2014-08-01
• Study First Posted: 2014-08-04
• Primary Completion: 2016-07
• Study Completion: 2021-12
• Status Verified: 2022-04
• Last Update Submitted: 2022-04-18
• Last Update Posted: 2022-04-20

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 1000

Inclusion Criteria

• Age > or = 3 months old
• Receiving a Lumbar Puncture in the emergency department as part of their standard care.

Exclusion Criteria

• No CSF available

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patients with syndromes requiring lumbar puncture	no intervention	-

Primary Outcome Measures

Name	Time	Method
prevalence of pathogens	2 years	We will describe the range and proportion of pathogens found in CSF among patients enrolled over a 2 year period.

Trial Locations

Locations (1)

Olive View-UCLA Medical Center; 🇺🇸 Sylmar, California, United States