Consumption of Fatty Acids, Metabolism of Adipose Tissue and Risk of Colorectal Cancer: AGARIC Case Control Study

Centre Hospitalier Universitaire Dijon5 个研究点分布在 1 个国家目标入组 551 人2008年9月15日

适应症First Recently-diagnosed Colorectal Cancer

干预措施Blood sample tissue samples from abdominal subcutaneous adipose

概览

阶段: 不适用
干预措施: Blood sample
疾病 / 适应症: First Recently-diagnosed Colorectal Cancer
发起方: Centre Hospitalier Universitaire Dijon
入组人数: 551
试验地点: 5
主要终点: Measure of polyunsaturated fatty acids in adipose tissue lipids.
状态: 已完成
最后更新: 2个月前

概览研究者入排标准研究组 & 干预措施结局指标研究点相似试验

概览

简要总结

The aim of the study is to establish the existence of a relationship between the dietary intake of polyunsaturated fatty acids (PUFA) and the risk of colorectal cancer in humans, using 2 reliable and complementary biomarkers: the fatty acid-composition of lipids of the abdominal subcutaneous adipose tissue and the fatty acid composition of erythrocyte phospholipids.

注册库

clinicaltrials.gov

开始日期

2008年9月15日

结束日期

2011年6月15日

最后更新

2个月前

研究类型

Interventional

研究设计

Parallel

性别

All

研究者

发起方

Centre Hospitalier Universitaire Dijon

责任方

Sponsor

入排标准

入选标准

•Patients aged ≥ 45 years
•with a first recently-diagnosed colorectal cancer
•due to undergo elective surgical resection with curative intent (in practice, stage I, II, III or IV if there was only one hepatic nodule that was resected with curative intent) in one of the 5 following digestive surgery units: CHU de Dijon, CHU de Nancy, CHU de Strasbourg, CHU de Reims et CHU and Besançon.
•who have given their informed consent
•Patients aged ≥ 45 years
•due to undergo surgery for a benign abdominal disease (sigmoid diverticulitis, appendectomy, hiatal hernia …)
•matched for abdominal site with cases for age (± 3 years), sex and hospital
•Who have given their informed consent

排除标准

•pre-operative anticancer treatment (chemo or radiotherapy)
•existence of visceral metastases except a single hepatic nodule resected with curative intent
•familial adenomatous polyposis and HNPCC syndrome (when suspected: inclusion after complementary tumor phenotype study: screening for microsatellite instability and/or immunohistochemistry study of the expression of DNA mismatch repair proteins.
•known inflammatory disease of the intestine (ulcerative colitis, Crohn's disease)
•personal history (recent or not) of colorectal cancer
•emergency treatment for the presenting complication (perforation, occlusion…)
•significant modification in dietary habits during the previous three months
•other evolving neoplastic disease
•psychic state incompatible with understanding the modalities and the aims of the study (notably patients under guardianship)
•pregnant or breast-feeding women