NL-OMON45667
Completed
Not Applicable
The Personalized Parkinson Project - PPP
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Parkinson's Disease
- Sponsor
- Radboud Universitair Medisch Centrum
- Enrollment
- 650
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Prior to enrollment in this clinical investigation, candidates must meet ALL of the following criteria:;\* Subject has Parkinson\*s disease of \<\=5 years duration, defined as time since diagnosis made by a neurologist.
- •\* Subject is an adult, at least 18 years of age.
- •\* Subject can read and understand Dutch.
- •\* Subject has completed the CMO\-approved Informed Consent.
- •\* Subject is willing, competent, and able to comply with all aspects of the protocol, including follow\-up schedule and biospecimen collection.
- •\* Subject is not a current or previous employee or family member of employees of the institutions involved in the study, including Verily Life Sciences and Radboudumc.
Exclusion Criteria
- •Candidates must be excluded from this study if ANY of the following criteria are met:;\* Subject is pregnant or breastfeeding.
- •\* Subject has co\-morbidities that would hamper interpretation of parkinsonian disability, such as coincident musculoskeletal abnormalities, in the opinion of the Investigator.
- •\* Contraindicated for MRI, e.g. claustrophobia, presence of an active implant, pacemaker, insulin pump, neurostimulator, ossicle prosthesis, and/or other medical device or other non\-removable metal part incompatible with MRI.
- •\* For lumbar puncture:
- •o Allergy to local anesthetic agents
- •o Medical history of compression of spinal cord, current local skin infection at the site of the lumbar puncture, developmental abnormalities in lower spine, blood coagulopathy, anticoagulant medication (Acenocoumarol, Warfarin, Dabigatran).
- •o Clinical (or previous MRI) evidence of structural cerebral abnormalities that are not compatible with the performance of a lumbar puncture such as malignancies, abscess, or obstructive hydrocephalus.
Outcomes
Primary Outcomes
Not specified
Similar Trials
Completed
Not Applicable
The Personalized Parkinson Project - de novo cohortParkinson's Disease10028037NL-OMON49224Radboud Universitair Medisch Centrum144
Completed
Not Applicable
Personalized Parkinson Project - Progressive Supranuclear Palsy cohortProgressive Supranuclear Palsy10028037NL-OMON49320Radboud Universitair Medisch Centrum100
Active, not recruiting
Not Applicable
The Personalized Parkinson Project (PPP)Parkinson DiseaseNCT03364894Radboud University Medical Center520
Recruiting
Not Applicable
The Parkinson*s Progression Markers Initiative (PPMI) Clinical - Establishing a Deeply Phenotyped PD CohortNL-OMON56457Michael J Fox Foundation75
Active, not recruiting
Not Applicable
The Parkinson's Progression Markers Initiative (PPMI)Parkinson DiseaseMedDRA version: 14.1Level: PTClassification code 10061536Term: Parkinson's diseaseSystem Organ Class: 10029205 - Nervous system disordersTherapeutic area: Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Diagnosis [E01]EUCTR2010-019894-13-ITMICHAEL J. FOX FOUNDATION FOR PARKINSON'S RESEARCH600