Treatment Of Depression In Patients With Temporal Lobe Epilepsy: Comparative Study Of Cognitive Behavioral Therapy Vs. Selective Serotonin Reuptake Inhibitors
Overview
- Phase
- N/A
- Intervention
- Cognitive behavioral therapy
- Conditions
- Depression
- Sponsor
- El Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez
- Enrollment
- 15
- Locations
- 1
- Primary Endpoint
- Change in Beck Depression Inventory score
- Status
- Completed
- Last Updated
- 11 years ago
Overview
Brief Summary
The aim of the study is to compare the effect of group-cognitive-behavioral therapy (CBT)versus treatment as usual with the selective serotonin reuptake inhibitor sertraline, in patients with diagnosis of temporal lobe epilepsy (TLE) and depressive disorder.
Detailed Description
patients with temporal lobe epilepsy and depression will be enrolled into one of two treatment modality. The first group will receive 12 group cognitive behavioral sessions. CBT is a psychotherapy focused on the recognition and change of distorted thoughts and maladaptive behaviors. The second group will receive treatment with the selective serotonin reuptake inhibitor sertraline or citalopram for 12 weeks. This antidepressant is wide used to treat depression in patients with TLE.
Investigators
Edgar Daniel Crail Melendez
Md
El Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez
Eligibility Criteria
Inclusion Criteria
- •With Major depressive disorder according to criteria from the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV)
- •Diagnosed with TLE according to the criteria of the International League Against Epilepsy
- •Literates had sign an informed consent
- •Patients on antidepressant treatments will be allowed to participate only if they had been at stable doses for more than 8 weeks and still show signs of significant depression
Exclusion Criteria
- •Patients with high risk of suicide who required hospitalization
- •Patients who abused or are dependent on drugs
- •Those with a history of head trauma six months prior to the interview
- •Patients who have any condition that would prevent them from understanding the study or the psychotherapeutic process, such as mental retardation, psychosis, delirium, dementia, etc
- •Patients who have previously received CBT
- •Patients who have started, an antidepressant drug the last 8 weeks
Arms & Interventions
Cognitive behavioral Therapy
CBT program to be used in group modality that focused on managing symptoms of depression in patients with epilepsy. 12 CBT sessions, consisting of one weekly 90-minute session for 12 consecutive weeks.
Intervention: Cognitive behavioral therapy
Selective serotonin euptake inhibitor
Patients will receive a SSRI (sertraline or citalopram) for 12 weeks. Dose will be adjusted every 4 weeks according to medical criteria.
Intervention: SSRI
Outcomes
Primary Outcomes
Change in Beck Depression Inventory score
Time Frame: baseline, 6 weeks and 12 weeks
Secondary Outcomes
- Quality of Life in Epilepsy Scale(baseline, 6 weeks and 12 weeks)
- Hospital anxiety and depression scale (HADS)(baseline, 4weeks and 12 weeks)