Pathophysiology of pain in Parkinson's disease: exploration of the serotonin system in positron emission tomography (PET [18F]-MPPF) - PD PAIN - RC31/21-0566

Centre Hospitalier Universitaire De Toulouse0 个研究点目标入组 34 人开始时间: 2023年1月27日最近更新: 2024年8月21日

适应症

试验速览

暂无简介。

•Patients with Parkinson's disease defined according to UKPDSBB criteria, Men and women aged between 40 and 80 years, Patients with stable anti-parkinsonian treatment for at least 4 weeks prior to inclusion, Patients with a MOCA score > 25, Patients with a HADS-D score = 11, Person affiliated or benefiting from a social security scheme., Free, informed and written consent signed by the participant and the investigator (at the latest on the day of inclusion and before any examination required by the research).

•Patients treated with second line therapy (deep brain stimulation, pump - duodopa and apokinon), Patients with a history of significant psychiatric pathology according to the investigator, Patients treated with drugs interacting with 5HT1A receptors in the previous 4 weeks (triptan, serotonergic antidepressants), Patients with contraindication to MRI, Patients refusing to be informed of an abnormality discovered during brain imaging, Patients with dyskinesias judged by the investigator to be disabling for imaging, Patients under guardianship or other legal protection, deprived of their liberty by judicial or administrative decision, Pregnant woman, breastfeeding woman

发起方