Pathophysiology of pain in Parkinson's disease: exploration of the serotonin system in positron emission tomography
- Conditions
- Parkinson's diseaseMedDRA version: 21.1Level: LLTClassification code: 10013113Term: Disease Parkinson's Class: 10029205Therapeutic area: Diseases [C] - Nervous System Diseases [C10]
- Registration Number
- CTIS2022-501123-24-00
- Lead Sponsor
- Centre Hospitalier Universitaire De Toulouse
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Recruiting
- Sex
- All
- Target Recruitment
- 34
Patients with Parkinson's disease defined according to UKPDSBB criteria, Men and women aged between 40 and 80 years, Patients with stable anti-parkinsonian treatment for at least 4 weeks prior to inclusion, Patients with a MOCA score > 25, Patients with a HADS-D score = 11, Person affiliated or benefiting from a social security scheme., Free, informed and written consent signed by the participant and the investigator (at the latest on the day of inclusion and before any examination required by the research).
Patients treated with second line therapy (deep brain stimulation, pump - duodopa and apokinon), Patients with a history of significant psychiatric pathology according to the investigator, Patients treated with drugs interacting with 5HT1A receptors in the previous 4 weeks (triptan, serotonergic antidepressants), Patients with contraindication to MRI, Patients refusing to be informed of an abnormality discovered during brain imaging, Patients with dyskinesias judged by the investigator to be disabling for imaging, Patients under guardianship or other legal protection, deprived of their liberty by judicial or administrative decision, Pregnant woman, breastfeeding woman
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method