Neurological Outcome After Mild Induced Hypothermia (MIH) After Restoration of Spontaneous Circulation
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Cardiac Arrest
- Sponsor
- University of Leipzig
- Enrollment
- 150
- Locations
- 1
- Primary Endpoint
- Neurological outcome after 6 month after MIH, Quality of life-survey
- Last Updated
- 16 years ago
Overview
Brief Summary
Sudden cardiac arrest (SCA) remains one of the major leading causes of death. Cognitive deficits are common in survivors of SCA. Postresuscitative mild induced hypothermia (MIH) lowers mortality and reduces neurologic damage after cardiac arrest. The investigators evaluated the long term neurological outcome after mild hypothermia after restoration of spontaneous circulation.
Detailed Description
Consecutive patients with restoration of spontaneous circulation (ROSC) after resuscitation due to out-of-hospital SCA, admitted to our intensive care unit, underwent MIH. Hypothermia was induced by infusion of cold saline and whole-body-cooling methods (electronic randomization: invasive Coolgard or non-invasive ArcticSun). The core body temperature was operated at 32 to 34 °C over a period of 24 hours followed by active rewarming. Neurological status was evaluated at hospital discharge and 6 months after discharge using the Pittsburgh Cerebral Performance Category (CPC).
Investigators
Eligibility Criteria
Inclusion Criteria
- •survived cardiac arrest
- •voluntary consent
Exclusion Criteria
- •no voluntary consent
Outcomes
Primary Outcomes
Neurological outcome after 6 month after MIH, Quality of life-survey
Time Frame: 6 Month
Neurological outcome after 6 month after MIH measured by questionnaire.
Secondary Outcomes
- Managing daily activities(6 Month)
- Neurological Outcome in consideration of the practice of the treating instances.(6 month)
- Neurological outcome depending of the beginning of MIH(6 month)
- Surviving after hospitalization(6 Month)