Examination of the growth suppressive effect of chemical compounds against T cell acute lymphoblastic leukemia (T-ALL) cells
Not Applicable
Recruiting
- Conditions
- T cell acute lymphoblastic leukemia
- Registration Number
- JPRN-UMIN000032249
- Brief Summary
We performed large-scale screening of natural compound libraries to identify potential drugs against T-ALL. We identified three low-molecular-weight compounds that inhibited the proliferation of the T-ALL cell line CCRF-CEM, but not that of the B lymphoma cell line Raji in a low concentration range. Among them, Auxarconjugatin-B suppressed the in vitro growth of five human T-ALL cell lines and two T-ALL patient-derived cells. These compounds are promising seeds for developing novel anti-T-ALL drugs.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 3
Inclusion Criteria
Not provided
Exclusion Criteria
non T-lineage leukemia
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method In vitro cell growth-suppressing activity
- Secondary Outcome Measures
Name Time Method