A comparison of the effects of 12 weeks walking with two different intensities on the expression of circulating miR-146a, miR-181a and Plasma levels of inflammatory markers IL-6 and TNF-a In Sedentary Aged Women.
Not Applicable
- Conditions
- Diseases associated with aging and inflammation.
- Registration Number
- IRCT20150531022498N23
- Lead Sponsor
- Rasht Azad University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 50
Inclusion Criteria
Women
Age range 60 to 75
Inactive
Exclusion Criteria
Having any chronic and inflammatory disease
Having any particular diet or medication during the study period
Use of auxiliary equipment for walking
Motor limitation in the pelvic, hip and knee joints
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Plasma level of miR-146a. Timepoint: Before and after the end of 12 weeks of training. Method of measurement: Using by polymerase chain reaction (PCR).;Plasma level of microRNA-181a. Timepoint: Before and after the end of 12 weeks of training. Method of measurement: Using by polymerase chain reaction (PCR).;Plasma level of Interleukin-6. Timepoint: Before and after the end of 12 weeks of training. Method of measurement: Serum level using ELISA Kit.;Plasma level of Tumor necrosis factor alpha (TNF-a). Timepoint: Before and after the end of 12 weeks of training. Method of measurement: Serum level using ELISA Kit.;White blood cell counts. Timepoint: Before and after the end of 12 weeks of training. Method of measurement: Using blood sample.
- Secondary Outcome Measures
Name Time Method Blood pressure variables. Timepoint: Before and after the end of 12 weeks of training. Method of measurement: Rest levels using by measurement of systolic blood pressure, diastolic blood pressure and heart rate.;Quality of life. Timepoint: Before and after the end of 12 weeks of training. Method of measurement: Using by quality of life questionnaire (SF-36).;Body composition. Timepoint: Before and after the end of 12 weeks of training. Method of measurement: Using by measurement of weight, body mass index (BMI), fat percent, fat free mass and waist circumference.;Physical fitness. Timepoint: Before and after the end of 12 weeks of training. Method of measurement: Using by measurement of dynamic and static balance and maximum oxygen consumption (VO2max).