NCT01017822撤回1 期
A Phase I/II Study of Induction Conatumumab and Gemcitabine, Followed by Conatumumab, Capecitabine and 3-D Conformal Radiation Therapy (3D-CRT) With Subsequent Maintenance Therapy for Locally Advanced Pancreatic Cancer
适应症
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 撤回
- 主要终点
- Dose-limiting toxicity (Phase I)
研究概览
简要总结
RATIONALE: Monoclonal antibodies, such as conatumumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Drugs used in chemotherapy, such as gemcitabine hydrochloride and capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy may uses high energy x-rays to kill tumor cells. Giving conatumumab together with gemcitabine hydrochloride, capecitabine, and radiation therapy may kill more tumor cells.
PURPOSE: This phase I/II trial is studying the side effects and best dose of conatumumab when given together with gemcitabine hydrochloride, capecitabine, and radiation therapy and to see how well they work in treating patients with locally advanced pancreatic cancer.
详细描述
OBJECTIVES:
Primary
- To evaluate the maximum tolerated dose of conatumumab up to a target dose of 10 mg/kg given concurrently with capecitabine and radiotherapy following induction therapy comprising conatumumab and gemcitabine hydrochloride in patients with locally advanced pancreatic cancer. (Phase I)
- To evaluate the overall survival of patients treated with this regimen. (Phase II)
Secondary
- To evaluate the safety profile in patients treated with this regimen. (Phase I and II)
- To evaluate the progression-free survival of patients treated with this regimen. (Phase II)
- To evaluate the primary tumor response rate in patients treated with this regimen. (Phase II)
- To generate translational research hypotheses. (Phase II)
研究设计
- 研究类型
- Interventional
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •DISEASE CHARACTERISTICS:
- •Histologically or cytologically confirmed adenocarcinoma of the pancreas
- •Locally advanced disease
- •With and without regional adenopathy
- •Unresectable disease based on institutional standardized criteria of unresectability OR medically inoperable
- •No distant metastatic disease, second malignancy, or peritoneal seeding
- •PATIENT CHARACTERISTICS:
- •Zubrod performance status 0-1
- •Absolute granulocyte count ≥ 1,500/mm³
- •Platelet count ≥ 100,000/mm³
- •Hemoglobin ≥ 8.0 g/dL (transfusion or other intervention allowed)
- •Serum creatinine ≤ 1.5 mg/dL
- •ALT or AST < 3 times upper limit of normal (ULN)
- •Total bilirubin < 3.0 mg/dL
- •Alkaline phosphatase < 3 times ULN
- •Amylase ≤ 2 times ULN
- •Lipase ≤ 2 times ULN
- •Not pregnant or nursing
- •Negative pregnancy test
- •Fertile patients must use effective contraception during and for ≥ 3 months after the last study drug administration (for women) or for ≥ 6 months after the last study drug administration (for men)
- •Able to swallow oral medications
- •No other invasive malignancy within the past 2 years, except for nonmelanomatous skin cancer or carcinoma in situ of the breast, oral cavity, or cervix
- •No severe, active co-morbidity, including any of the following:
- •Chronic obstructive pulmonary disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy within the past 30 days
- •Transmural myocardial infarction within the past 3 months
- •Unstable angina and/or congestive heart failure requiring hospitalization within the past 6 months
- •Any other cardiac condition that, in the opinion of the treating physician, would make study treatment unreasonably hazardous for the patient
- •Acute bacterial or fungal infection requiring IV antibiotics
- •Uncontrolled malabsorption syndrome significantly affecting gastrointestinal function
- •Any unresolved bowel or bile duct obstruction
- •Major resection of the stomach or small bowel that could affect the absorption of capecitabine
- •AIDS based upon current CDC definition
- •HIV testing is not required for study entry
- •No prior allergic reaction to capecitabine or gemcitabine hydrochloride
- •PRIOR CONCURRENT THERAPY:
- •No prior radiotherapy to the region of the study cancer that would result in overlap of radiotherapy fields
- •No prior treatment with TRAIL-receptor agonists
- •No prior systemic chemotherapy for pancreatic cancer
- •More than 2 years since prior chemotherapy for malignancies other than pancreatic cancer
- •More than 28 days since prior major surgery (e.g., biliary or gastric bypass)
- •Insertion of a vascular access device, exploratory laparotomy, or laparoscopy are not considered major surgery
- •No concurrent intensity-modulated radiotherapy
- •No other concurrent chemotherapy
- •No other concurrent monoclonal antibody therapy
- •No concurrent sorivudine, brivudine A, or cimetidine
- •No concurrent participation in another clinical trial
- •Concurrent oral anticoagulants (e.g., warfarin) allowed provided INR is monitored
排除标准
- 未提供
结局指标
主要结局
Dose-limiting toxicity (Phase I)
Overall survival (Phase II)
次要结局
- Adverse events (Phase I and II)
- Progression-free survival (Phase II)
- Response rate (Phase II)
研究者
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