Study of Retinal Function Using Electroretinogram in Regular Alcohol Users
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- modification of amplitude
研究概览
简要总结
Alcohol is a major public health problem and its neurotoxic effects are, among other things, responsible for altering the functioning of cerebral neurotransmission pathways.
The retina is an anatomical and developmental extension of the central nervous system. It is composed of several layers of retinal neurons that share similar anatomical and functional properties with brain neurons. Retinal neurons are notably equipped with a complex system of neurotransmission constituted by the main neurotransmitters that are involved in the central effects of alcohol: glutamate, dopamine, serotonin ... The retina is used here as a site of indirect investigation for abnormal central neurotransmission pathways following regular alcohol use. It is recognized to date as a good site for investigating central abnormalities in neuropsychiatric and addictive disorders.
The objective of this project is to study the retinal function using electroretinogram (ERG) in regular alcohol users to isolate potential markers of cerebral neurotransmission abnormalities.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •For alcohol consumer with alcohol use disorder :
- •Inclusion Criteria:
- •aged between 18 and 35 years
- •alcohol use disorder according to the DSM 5
- •affiliation to a social security scheme
排除标准
- •psychoactive substance consumption (other than alcohol)
- •psychiatric disease in progress according to the DSM 5
- •neurologic disease in progress
- •mental impairment making it difficult or impossible to participate to the study
- •major under guardianship or curatorship or under safeguarding of justice
- •pregnant women or feeding
- •people in emergency situation
- •participation to another interventional study
- •retinal disease in progress
- •chronic glaucoma
- •ophtalmic disease affecting the visual acuity
- •ocular infection in progress
- •urinary positive drug check the day of the inclusion
- •postive Breathalyser the day of the inclusion
研究组 & 干预措施
alcohol consumption with alcohol use disorder (AUD)
subjects with regular alcohol consumption with AUD according to the DSM 5 without any other substance use disorder (except alcohol) without psychiatric, neurologic or ophthalmologic disease in progress with a negative drug check and Breathalyzer the day of the inclusion - only one visit is planned for this study : an electroretinogram will be realized
干预措施: electroretinogram (flash, pattern and multifocal) (Other)
alcohol consumption without alcohol use disorder
subjects with regular alcohol consumption without AUD according to the DSM 5 without any other substance use disorder without psychiatric, neurologic or ophthalmologic disease in progress with a negative drug check and Breathalyzer the day of the inclusion - only one visit is planned for this study : an electroretinogram will be realized
干预措施: electroretinogram (flash, pattern and multifocal) (Other)
no alcohol consumption
subjects without alcohol consumption without any other substance use disorder without psychiatric, neurologic or ophthalmologic disease in progress with a negative drug check and Breathalyzer the day of the inclusion - only one visit is planned for this study : an electroretinogram will be realized
干预措施: electroretinogram (flash, pattern and multifocal) (Other)
结局指标
主要结局
modification of amplitude
时间窗: Day 0 (=day of inclusion = the only visit of the study)
measured with flash electroretinogram and pattern electroretinogram / amplitude in microvolt
modification of implicite time parameters
时间窗: Day 0 (=day of inclusion = the only visit of the study)
measured with flash electroretinogram and pattern electroretinogram - implicite time in millisecond
modification of amplitude of the oscillatory potential
时间窗: Day 0 (=day of inclusion = the only visit of the study)
waves P1, P2, P3, P4 measured with flash electroretinogram - amplitude in microvolt
modification of implicit time of the oscillatory potential
时间窗: Day 0 (=day of inclusion = the only visit of the study)
waves P1, P2, P3, P4 measured with flash electroretinogram - implicite time in millisecond
modification of amplitude of the background noise
时间窗: Day 0 (=day of inclusion = the only visit of the study)
measured with the flash electroretinogram, flicker 3.0 sequence - amplitude in microvolt
次要结局
未报告次要终点