Study of Retinal Function Using Electroretinogram in Regular Alcohol Users
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Alcohol Use Disorder
- Sponsor
- Centre Psychothérapique de Nancy
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- modification of amplitude
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
Alcohol is a major public health problem and its neurotoxic effects are, among other things, responsible for altering the functioning of cerebral neurotransmission pathways.
The retina is an anatomical and developmental extension of the central nervous system. It is composed of several layers of retinal neurons that share similar anatomical and functional properties with brain neurons. Retinal neurons are notably equipped with a complex system of neurotransmission constituted by the main neurotransmitters that are involved in the central effects of alcohol: glutamate, dopamine, serotonin ... The retina is used here as a site of indirect investigation for abnormal central neurotransmission pathways following regular alcohol use. It is recognized to date as a good site for investigating central abnormalities in neuropsychiatric and addictive disorders.
The objective of this project is to study the retinal function using electroretinogram (ERG) in regular alcohol users to isolate potential markers of cerebral neurotransmission abnormalities.
Investigators
Eligibility Criteria
Inclusion Criteria
- •aged between 18 and 35 years
- •alcohol use disorder according to the DSM 5
- •affiliation to a social security scheme
Exclusion Criteria
- •psychoactive substance consumption (other than alcohol)
- •psychiatric disease in progress according to the DSM 5
- •neurologic disease in progress
- •mental impairment making it difficult or impossible to participate to the study
- •major under guardianship or curatorship or under safeguarding of justice
- •pregnant women or feeding
- •people in emergency situation
- •participation to another interventional study
- •retinal disease in progress
- •chronic glaucoma
Outcomes
Primary Outcomes
modification of amplitude
Time Frame: Day 0 (=day of inclusion = the only visit of the study)
measured with flash electroretinogram and pattern electroretinogram / amplitude in microvolt
modification of implicite time parameters
Time Frame: Day 0 (=day of inclusion = the only visit of the study)
measured with flash electroretinogram and pattern electroretinogram - implicite time in millisecond
modification of amplitude of the oscillatory potential
Time Frame: Day 0 (=day of inclusion = the only visit of the study)
waves P1, P2, P3, P4 measured with flash electroretinogram - amplitude in microvolt
modification of implicit time of the oscillatory potential
Time Frame: Day 0 (=day of inclusion = the only visit of the study)
waves P1, P2, P3, P4 measured with flash electroretinogram - implicite time in millisecond
modification of amplitude of the background noise
Time Frame: Day 0 (=day of inclusion = the only visit of the study)
measured with the flash electroretinogram, flicker 3.0 sequence - amplitude in microvolt