Study of Retinal Function Using Electroretinogram in Regular Alcohol Users
- Conditions
- Alcohol Use Disorder
- Interventions
- Other: electroretinogram (flash, pattern and multifocal)
- Registration Number
- NCT03818971
- Lead Sponsor
- Centre Psychothérapique de Nancy
- Brief Summary
Alcohol is a major public health problem and its neurotoxic effects are, among other things, responsible for altering the functioning of cerebral neurotransmission pathways.
The retina is an anatomical and developmental extension of the central nervous system. It is composed of several layers of retinal neurons that share similar anatomical and functional properties with brain neurons. Retinal neurons are notably equipped with a complex system of neurotransmission constituted by the main neurotransmitters that are involved in the central effects of alcohol: glutamate, dopamine, serotonin ... The retina is used here as a site of indirect investigation for abnormal central neurotransmission pathways following regular alcohol use. It is recognized to date as a good site for investigating central abnormalities in neuropsychiatric and addictive disorders.
The objective of this project is to study the retinal function using electroretinogram (ERG) in regular alcohol users to isolate potential markers of cerebral neurotransmission abnormalities.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 60
- aged between 18 and 35 years
- alcohol use disorder according to the DSM 5
- affiliation to a social security scheme
- psychoactive substance consumption (other than alcohol)
- psychiatric disease in progress according to the DSM 5
- neurologic disease in progress
- mental impairment making it difficult or impossible to participate to the study
- major under guardianship or curatorship or under safeguarding of justice
- pregnant women or feeding
- people in emergency situation
- participation to another interventional study
- retinal disease in progress
- chronic glaucoma
- ophtalmic disease affecting the visual acuity
- ocular infection in progress
- urinary positive drug check the day of the inclusion
- postive Breathalyser the day of the inclusion
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description alcohol consumption without alcohol use disorder electroretinogram (flash, pattern and multifocal) subjects with regular alcohol consumption without AUD according to the DSM 5 without any other substance use disorder without psychiatric, neurologic or ophthalmologic disease in progress with a negative drug check and Breathalyzer the day of the inclusion - only one visit is planned for this study : an electroretinogram will be realized no alcohol consumption electroretinogram (flash, pattern and multifocal) subjects without alcohol consumption without any other substance use disorder without psychiatric, neurologic or ophthalmologic disease in progress with a negative drug check and Breathalyzer the day of the inclusion - only one visit is planned for this study : an electroretinogram will be realized alcohol consumption with alcohol use disorder (AUD) electroretinogram (flash, pattern and multifocal) subjects with regular alcohol consumption with AUD according to the DSM 5 without any other substance use disorder (except alcohol) without psychiatric, neurologic or ophthalmologic disease in progress with a negative drug check and Breathalyzer the day of the inclusion - only one visit is planned for this study : an electroretinogram will be realized
- Primary Outcome Measures
Name Time Method modification of amplitude Day 0 (=day of inclusion = the only visit of the study) measured with flash electroretinogram and pattern electroretinogram / amplitude in microvolt
modification of implicite time parameters Day 0 (=day of inclusion = the only visit of the study) measured with flash electroretinogram and pattern electroretinogram - implicite time in millisecond
modification of amplitude of the oscillatory potential Day 0 (=day of inclusion = the only visit of the study) waves P1, P2, P3, P4 measured with flash electroretinogram - amplitude in microvolt
modification of implicit time of the oscillatory potential Day 0 (=day of inclusion = the only visit of the study) waves P1, P2, P3, P4 measured with flash electroretinogram - implicite time in millisecond
modification of amplitude of the background noise Day 0 (=day of inclusion = the only visit of the study) measured with the flash electroretinogram, flicker 3.0 sequence - amplitude in microvolt
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Centre Psychothérapique de Nancy
🇫🇷Laxou, Nancy, France