Risk of Venous Thromboembolism in Critically Ill Patients With Severe COVID-19
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- COVID-19
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
- Enrollment
- 230
- Locations
- 3
- Primary Endpoint
- Venous thromboembolisms
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
Severe COVID-19 patients at a high risk of venous thromboembolism. We studied patients in 2 intensive care units of university hospitals in Barcelona and Badalona, Spain. We performed a cut-off screening of deep venous thrombosis (DVT) with bilateral duplex ultrasound to 230 patients.
Detailed Description
SARS-CoV-2 infection has been associated with coagulation disorders and increased risk of venous thromboembolism (VTE). The aim of the study is to determine the cumulative incidence of VTE in critically ill patients with COVID-19 and its impact on prognosis. Methods Cohort study of critically ill patients due to COVID-19. A bilateral venous compression (CUS) ultrasound screening of the lower extremities was performed during a cut-off period in 2 intensive care units of university hospitals in Spain. Asymptomatic and symptomatic VTE were registered: pulmonary embolism (PE) (diagnosed by CT-angiography) and deep venous thrombosis (DVT). The characteristics of the patients, results of their blood tests and their evolution after 7 days of follow-up were recorded.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients with severe COVID-19 pneumonia admitted to the intensive care unit
Exclusion Criteria
- •Treatment with Extracorporeal membrane oxygenation (ECMO)
- •Pregnant or postpartum women
- •Under 18 years old
Outcomes
Primary Outcomes
Venous thromboembolisms
Time Frame: 7 days
Patients with symptomatic pulmonary embolism confirmed on the CT-angiography and those with a swollen limb and confirmed deep venous thrombosis on compression ultrasound were considered to have "symptomatic venous thromboembolisms". The remaining patients with positive limb ultrasound or CT-angiography were considered to have "asymptomatic venous thrombembolism"
Secondary Outcomes
- Deaths(7 days)