Brain structure and neurocognitive development in sickle cell disease; a longitudinal cohort study (BRICK study)
Recruiting
- Conditions
- Sickle Cell Disease1004225810047075
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 114
Inclusion Criteria
• Patients with sickle cell disease of all genotypes;
Exclusion Criteria
• Parents/ guardians (in case of minors) or patients themselves (>16 years)
unable to make an informed decision on participating in this study.
• An abnormal brain MRI prior to initiation of the study due to non-SCD related
causes.
• Contraindications for brain MRI per protocol
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>• Total white matter volume increase in children and adolescents with SCD</p><br>
- Secondary Outcome Measures
Name Time Method <p>• Neurocognitive functioning (intelligence, specific neurocognitive functions,<br /><br>network organization)<br /><br>• Incidence of stroke<br /><br>• Other forms complications due to SCD<br /><br>• Amount of hospital admissions, day care admissions (adult care only), crises<br /><br>at home, contact moments with the sickle cell center, ER visits<br /><br>• Biomarkers for anemia, hemolysis, inflammation and endothelial activation.<br /><br>• Behavioral functioning</p><br>