Effects of periodontitis treatment on oral bacteria and glucose metabolism
Not Applicable
- Conditions
- Diabetes mellitus and Periodontitis
- Registration Number
- JPRN-UMIN000025706
- Lead Sponsor
- Shimane University Faculty of Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up continuing
- Sex
- All
- Target Recruitment
- 24
Inclusion Criteria
Not provided
Exclusion Criteria
1)The number of residual teeth is <12. 2)Received oral therapy within past 3 months. 3)Undergoing insulin therapy. 4)Changed abruptly in HbA1c level >=2% within past 3 months. 5)Current morbidity with acute infection, malignant disease or dementia. 6)Past history of hypersensitivity against Tetracycline antibiotics. 7)Past history of shock against the component of Amoxicillin capsules. 8)Past history of hypersensitivity against the component of Amoxicillin capsules or Penicillin antibiotics. 9)Infected by Infectious mononucleosis.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method More than 25% of patients whose HbA1c level decreases 0.5% or more after the final treatment (3 months later), compared to that of the basal level.
- Secondary Outcome Measures
Name Time Method HbA1c level is compared to that of historical control (past 3 months changes before the treatment). The other parameters (fasting blood sugar, insulin, HOMA-IR, blood pressure, lipids, liver function, urinary protein, changes of the number and species of oral bacteria, gingival index score, gingival bleeding, CRP, IL-6, and TNFalpha) are compared to those of the basal level.