Rheumatology Patient Registry and Biorepository
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 5,000
- 试验地点
- 1
- 主要终点
- Correlate outcomes and biomarkers of rheumatic diseases
研究概览
简要总结
To facilitate clinical, basic science, and translational research projects involving the study of rheumatic diseases.
详细描述
A rheumatology biorepository will be created to permit comparative analyses between the rheumatic diseases in order to increase the understanding of disease pathogenesis. Patients seen at Yale clinics diagnosed with rheumatic diseases are invited to participate in this study. These rheumatic diseases include, but are not limited to: adult onset Still's disease, ankylosing spondylitis, psoriatic arthritis, reactive arthritis, antiphospholipid syndrome, systemic lupus erythematosus, Behcet's disease, dermatomyositis, polymyositis, giant cell arteritis and other vasculitides, Lyme's disease, mixed connective tissue disease, polymyalgia rheumatica, rheumatoid arthritis, sarcoidosis, systemic sclerosis (scleroderma), Sjogren's syndrome, and undifferentiated connective tissue disease.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 99 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •for Rheumatology Patients:
- •Patients ≥18 years old with a diagnosis of a rheumatic autoimmune disease including, but not limited to: adult onset Still's disease, ankylosing spondylitis, antiphospholipid syndrome, Behcet's disease, dermatomyositis, giant cell arteritis, mixed connective tissue disease, polymyalgia rheumatica, polymyositis, psoriatic arthritis, reactive arthritis, rheumatoid arthritis, sarcoidosis, scleroderma, Sjogren's syndrome, systemic lupus erythematosus, undifferentiated connective tissue disease and vasculitis.
- •Receiving clinical care at Yale Rheumatology clinics
排除标准
- •for Rheumatology Patients:
- •Unable to provide informed consent
- •No patients will be excluded based on gender or ethnicity or pregnancy status.
- •Women who are currently pregnant will need to wait to donate a skin biopsy until after they deliver.
- •Patients allergic to lidocaine or epinephrine or have a history of impaired wound healing will not be able to donate a skin biopsy.
- •Inclusion Criteria for Healthy Volunteers:
- •Age ≥ 18 years old
- •No chronic skin conditions
- •No diagnosis of a rheumatic autoimmune disease (e.g., lupus, rheumatoid arthritis)
- •Normal BMI
- •Exclusion Criteria for Healthy Volunteers:
- •Unable to provide informed consent.
- •Currently pregnant or nursing unless the study goal is to study pregnant or nursing woman.
- •Allergies to lidocaine or epinephrine (skin biopsies).
- •A history of impaired wound healing (skin biopsies).
研究组 & 干预措施
Biorepository
Participants with rheumatic diseases who contributed biospecimen samples (blood, saliva, urine, stool, tissue).
结局指标
主要结局
Correlate outcomes and biomarkers of rheumatic diseases
时间窗: 10 years
Evaluate clinical data and biospecimens to correlate outcomes and biomarkers of rheumatic diseases.
次要结局
未报告次要终点