MRSA Colonization in Peripartum Women and Their Offspring

Completed

• Conditions: Pregnancy; Bacterial Colonization

• Registration Number: NCT00336427
• Lead Sponsor: Orlando Regional Medical Center

Brief Summary

We hypothesize that pregnant women are at baseline risk for carrying community-acquired MRSA, but also have frequent contact with healthcare workers which may put them at risk for hospital-acquired MRSA carriage. Our study aimed to identify the colonization rate of women in active labor and whether transmission to infants may occur.

Detailed Description

Mothers are at risk for carrying MRSA. What this risk is is not known. We have seen a dramatic increase in neonatal intensive care unit MRSA infections. Could mothers transmit MRSA to their newborns if they are asymptomatic carriers? Mothers come into close contact with health care providers, often have other children in daycare (known risk factor) and may have other exposures to MRSA. Our study was designed to sample 300 mother-infant pairs to determine whether MRSA carriage is present in asymptomatic women. The study consisted of obtaining informed consent, then performing a sterile swab of mothers' nares and vaginal area, then babies' nares and umbilicus once the baby was born.

Study Timeline

• Study Start: 2005-09
• Status Verified: 2006-05
• Study Completion: 2006-05
• Study First Submitted: 2006-06-09
• Study First Submitted QC: 2006-06-09
• Last Update Submitted: 2006-06-09
• Study First Posted: 2006-06-13
• Last Update Posted: 2006-06-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 600

Inclusion Criteria

• Singleton pregnancy expected to deliver next 24 hours

Exclusion Criteria

• Cesarean sections

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified