Interventional Prospective Cohort Study, Multi-center With Nested Case-control Studies (Family-based and Non-family Based) on Individuals With Resistant Arterial Hypertension.
Overview
- Phase
- Not Applicable
- Intervention
- chlorthalidone
- Conditions
- Hypertension
- Sponsor
- University Hospital, Geneva
- Enrollment
- 74
- Locations
- 3
- Primary Endpoint
- blood pressure control
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
The purpose of this study is to investigate the epidemiology of resistant hypertension, evaluate the efficacy and feasibility of a standardized drug treatment regimen (including the randomization of two doses of the diuretic used - chlorthalidone), study two interventions in the group of patients that is non-compliant, and study environmental and genetic variables of individuals with resistant hypertension in a family design.
Investigators
Georg EHRET
intern
University Hospital, Geneva
Eligibility Criteria
Inclusion Criteria
- •informed consent
- •resistant hypertension at the moment of inclusion
- •18 years or more, both sexes are included
- •women at reproductive age: consenting to use oral contraception
Exclusion Criteria
- •patients mentally impaired or unable to give informed consent
- •patients speaking only a foreign language other than French, German, or English
- •patients living far away, making the study visits not practical
Arms & Interventions
chlorthalidone
Intervention: chlorthalidone
motivational invervention
motivational interview(s) vs. repeated calls vs. no particular intervention
Intervention: motivational intervention for non-compliant individuals
standardized anti-hypertensive treatment
Intervention: standardized anti-hypertensive treatment
Outcomes
Primary Outcomes
blood pressure control
Time Frame: at 12 weeks after initiation of standard treatment
Secondary Outcomes
- cardiovascular morbidity and mortality(5 years)