Comparison of ADR Using NBI Versus HD White Light Colonoscopy in Screening and Surveillance Colonoscopies

Not Applicable

Completed

• Conditions: Narrow Band Imaging
• Interventions: Device: HD white light or NBI

• Registration Number: NCT03081975
• Lead Sponsor: Jena University Hospital

Brief Summary

The aim of this study is to compare ADR using HD-NBI or HD-WLE during screening and surveillance colonoscopies.

Detailed Description

Background:

Despite recent advances in endoscopic technology adenoma miss rate still is up to 20% and contributes to the occurrence of interval cancers. Therefore, improved imaging modalities have been introduced to increase adenoma detection rate (ADR) during screening and surveillance colonoscopies. Recently, narrow band imaging (NBI; Exera II series, Olympus Corporation) was not significantly better than high definition white light colonoscopy (WLC) for the detection of patients with colorectal polyps, or colorectal adenomas1. However, Olympus' current Exera III series is characterized by better illumination of the bowel lumen and may be associated with a higher ADR than high definition WLC.

Methods:

Investigators performed a prospective evaluation in patients referred to the Department of Interdisciplinary Endoscopy at Jena University Hospital for screening or surveillance colonoscopy between January and November 2015 in daily clinical practice. Colonoscopy was performed by use of HD-WLC or HD-NBI upon withdrawal of the colonoscope (Exera III series, Olympus Corporation).

Study Timeline

• Study Start: 2015-01
• Study First Submitted: 2017-03-04
• Study First Submitted QC: 2017-03-16
• Study First Posted: 2017-03-17
• Primary Completion: 2017-12
• Study Completion: 2017-12
• Status Verified: 2018-03
• Last Update Submitted: 2018-03-17
• Last Update Posted: 2018-03-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 500

Inclusion Criteria

• Screening colonoscopies

Exclusion Criteria

• Insufficient bowel cleansing
• Age under 55years

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
HD narrow band imaging	HD white light or NBI	Colonoscopy was performed by use of HD-WLC or HD-NBI upon withdrawal
HD white light	HD white light or NBI	Colonoscopy was performed by use of HD-WLC or HD-NBI upon withdrawal

Primary Outcome Measures

Name	Time	Method
Adenoma detection rate	up to 60min	Adenoma detection rate

Trial Locations

Locations (1)

University Clinic Jena; 🇩🇪 Jena, Thueringia, Germany