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临床试验/NCT03081975
NCT03081975已完成不适用

Comparison of Adenoma Detection Rate Using Narrow Band Imaging Versus HD White Light Colonoscopy in Screening and Surveillance Colonoscopies

Jena University Hospital2 个研究点 分布在 1 个国家目标入组 500 人开始时间: 2015年1月最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
入组人数
500
试验地点
2
主要终点
Adenoma detection rate

研究概览

简要总结

The aim of this study is to compare ADR using HD-NBI or HD-WLE during screening and surveillance colonoscopies.

详细描述

Background:

Despite recent advances in endoscopic technology adenoma miss rate still is up to 20% and contributes to the occurrence of interval cancers. Therefore, improved imaging modalities have been introduced to increase adenoma detection rate (ADR) during screening and surveillance colonoscopies. Recently, narrow band imaging (NBI; Exera II series, Olympus Corporation) was not significantly better than high definition white light colonoscopy (WLC) for the detection of patients with colorectal polyps, or colorectal adenomas1. However, Olympus' current Exera III series is characterized by better illumination of the bowel lumen and may be associated with a higher ADR than high definition WLC.

Methods:

Investigators performed a prospective evaluation in patients referred to the Department of Interdisciplinary Endoscopy at Jena University Hospital for screening or surveillance colonoscopy between January and November 2015 in daily clinical practice. Colonoscopy was performed by use of HD-WLC or HD-NBI upon withdrawal of the colonoscope (Exera III series, Olympus Corporation).

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Diagnostic
盲法
None

入排标准

年龄范围
55 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Screening colonoscopies

排除标准

  • Insufficient bowel cleansing
  • Age under 55years

研究组 & 干预措施

HD white light

Active Comparator

Colonoscopy was performed by use of HD-WLC or HD-NBI upon withdrawal

干预措施: HD white light or NBI (Device)

HD narrow band imaging

Active Comparator

Colonoscopy was performed by use of HD-WLC or HD-NBI upon withdrawal

干预措施: HD white light or NBI (Device)

结局指标

主要结局

Adenoma detection rate

时间窗: up to 60min

Adenoma detection rate

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Martin Bürger

Narrow band imaging does not increase adenoma detection rate compared to high definition white light colonoscopy in screening and surveillance colonoscopies

Jena University Hospital

研究点 (2)

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