FTO Gene Variants and Diet in Obesity

Completed

• Conditions: Obesity; Genetic Predisposition; Diet Habit

• Registration Number: NCT04205318
• Lead Sponsor: Hacettepe University

Brief Summary

Studies have shown that the effect of fat mass and obesity-associated (FTO) gene on obesity is modulated by lifestyle factors. Hence, we aimed to determine whether two single nucleotide polymorphisms (SNPs) in the FTO gene are associated with obesity and to assess whether these associations were modified by lifestyle factors. The study included 200 obese and 200 non-obese individuals from Turkey. Our study suggests that the effect of the SNPs on obesity traits is likely to be influenced by lifestyle factors in this Turkish population.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2017-03-01
• Primary Completion: 2018-02-01
• Study Completion: 2018-12-31
• Study First Submitted: 2019-07-21
• Status Verified: 2019-08
• Study First Submitted QC: 2019-12-17
• Last Update Submitted: 2019-12-17
• Study First Posted: 2019-12-19
• Last Update Posted: 2019-12-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 400

Inclusion Criteria

1. attending routine outpatient visits,
2. aged 24 to 50 years,
3. having a BMI ≥ 18.50 kg/m2

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Exclusion Criteria

Not provided

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Anthropometric measurements	up to 36 weeks	Body mass index, waist circumference, hip circumference, body composition
Biochemical measurements	up to 36 weeks	lipid profile, glucose, insulin, adiponectin
Genetic analysis of two SNPs at FTO gene	up to 36 weeks	FTO SNPs rs9939609 and rs10163409

Trial Locations

Locations (1)

Zehra Buyuktuncer; 🇹🇷 Ankara, Turkey