Impact of FTO Gene Variants and Lifestyle Factors on Obesity Traits in a Turkish Population
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 400
- 试验地点
- 1
- 主要终点
- Biochemical measurements
研究概览
简要总结
Studies have shown that the effect of fat mass and obesity-associated (FTO) gene on obesity is modulated by lifestyle factors. Hence, we aimed to determine whether two single nucleotide polymorphisms (SNPs) in the FTO gene are associated with obesity and to assess whether these associations were modified by lifestyle factors. The study included 200 obese and 200 non-obese individuals from Turkey. Our study suggests that the effect of the SNPs on obesity traits is likely to be influenced by lifestyle factors in this Turkish population.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 24 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •attending routine outpatient visits,
- •aged 24 to 50 years,
- •having a BMI ≥ 18.50 kg/m2
排除标准
- 未提供
结局指标
主要结局
Biochemical measurements
时间窗: up to 36 weeks
lipid profile, glucose, insulin, adiponectin
Anthropometric measurements
时间窗: up to 36 weeks
Body mass index, waist circumference, hip circumference, body composition
Genetic analysis of two SNPs at FTO gene
时间窗: up to 36 weeks
FTO SNPs rs9939609 and rs10163409
次要结局
未报告次要终点
研究者
ZEHRA BUYUKTUNCER
Professor
Hacettepe University