Regulation of Endothelial Progenitor Cells by Short-Term Exercise

Not Applicable

Completed

• Conditions: Cardiovascular Disease; Exercise; Aging
• Interventions: Other: Exercise Cessation; Other: Exercise Training

• Registration Number: NCT01169831
• Lead Sponsor: Baltimore VA Medical Center

Brief Summary

Endothelial Progenitor Cells (EPCs) are circulating cells released from bone marrow which are important for maintaining cardiovascular health. The prevalence of cardiovascular disease in older adults is associated with reduced circulating EPC numbers. Studies have shown reduced EPC number and function in old vs. young individuals, and endurance exercise training increases EPC number and function in young adults. Oxidative stress adversely affects endothelial cells and preliminary evidence indicates that oxidative stress negatively affects EPC function. Conversely, regular exercise reduces markers of oxidative stress and may enhance EPC function in older adults. The investigators hypothesize that older endurance-trained athletes and matched sedentary individuals will have markedly divergent EPC function and that altering the physical activity levels of both groups will move them to intermediate points between these two extremes. The investigators also propose that the investigators can "mimic" the effect of exercise training on EPC function in cell culture by altering intracellular levels of a key enzyme and a signaling molecule which the investigators have shown to regulate EPC function with respect to exercise training in young individuals.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2010-07-23
• Study First Submitted QC: 2010-07-23
• Study First Posted: 2010-07-26
• Study Start: 2011-07
• Primary Completion: 2014-11
• Study Completion: 2024-07-31
• Status Verified: 2024-08
• Last Update Submitted: 2024-08-20
• Last Update Posted: 2024-08-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• 50-80 years of age, BMI = 18-35 kg/m2, non-smoking, women must be postmenopausal

Exclusion Criteria

• history of cardiovascular/cerebrovascular disease, diabetes, cancer, renal, liver disease, HIV; uncontrolled hyperlipidemia/hypertension

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Older Endurance Athletes	Exercise Cessation	-
Sedentary Older Adults	Exercise Training	-

Primary Outcome Measures

Name	Time	Method
Baseline Endothelial progenitor cell number	Day 1
Final Endothelial Progenitor Cell Number	Day 15

Secondary Outcome Measures

Name	Time	Method
Final Endothelial Reactivity	Day 15
Baseline Endothelial Reactivity	Day 1

Trial Locations

Locations (1)

University of Maryland, Baltimore & Baltimore VA Medical Center; 🇺🇸 Baltimore, Maryland, United States