A study for investigating effects on the brain, heart, clotting system during and after pregnancy and the pregnant woman's and partner's health in the postpartum period in pregnancies complicated by preeclampsia

Not Applicable

• Conditions: Organ impairment in preeclampsia; Pregnancy and Childbirth; Pre-eclampsia

• Registration Number: ISRCTN13060768
• Lead Sponsor: Sahlgrenska University Hospital

Brief Summary

2021 Protocol article in https://pubmed.ncbi.nlm.nih.gov/34819281/ (added 26/11/2021) 2023 Results article in https://pubmed.ncbi.nlm.nih.gov/37080010/ (added 17/08/2023)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-07-27
• Last Update Posted: 28 August 2023
• Study Completion: 2032-12-31

Recruitment & Eligibility

• Status: Ongoing
• Sex: Female
• Target Recruitment: 300

Inclusion Criteria

Preeclampsia cohort:
1. Primiparous and parous pregnant women
2. Aged =18 years
3. Diagnosis of preeclampsia after gestational week 20

Control cohort:
1. Primiparous and parous women
2. Aged =18 years
3. Healthy pregnancies matched for gestational age

Exclusion Criteria

Current participant exclusion criteria as of 10/01/2022:
1. Unable to give written informed consent
2. Magnetic resonance imaging (MRI) contraindications, including claustrophobia, for MR group only
3. Diabetes Mellitus before or during pregnancy, pre-existing cardiovascular, renal, or cerebral disease, or pre-existing hypertension for special investigations including MRI, echocardiography, cerebral doppler measurements, and cognitive function assessment

Previous participant exclusion criteria:
1. Unable to give written informed consent
2. Pre-existing hypertension
3. Diabetes Mellitus before or during pregnancy
4. Pre-existing cardiovascular, renal, or cerebral disease
5. Magnetic resonance imaging (MRI) contraindications, including claustrophobia, for MR group only

Study & Design

• Study Type: Observational
• Study Design: Not specified