Effectiveness if Premedication With Single Dose Piroxicam and Prednisolone After a Single Visit Root Canal Treatment .

Phase 2

Completed

• Conditions: Post-operative Endodontic Pain
• Interventions: Drug: Piroxicam 20 mg; Drug: prednisolone 20 mg

• Registration Number: NCT04124822
• Lead Sponsor: Dow University of Health Sciences

Brief Summary

Two drugs (Piroxicam and Prednisolone)are being compared for post operative endodontic pain after a single visit root canal treatment for 74 hours.

Detailed Description

To evaluate effectiveness of single dose premedication with piroxicam(20mg) and prednisolone(20mg) on post endodontic pain after a single visit root canal treatment .

patient will be recalled every day for 4 days to know the pain scale using visual analogue scale .

Study Timeline

• Study Start: 2018-05-30
• Primary Completion: 2019-07-15
• Study Completion: 2019-07-15
• Study First Submitted: 2019-08-19
• Status Verified: 2019-10
• Study First Submitted QC: 2019-10-10
• Last Update Submitted: 2019-10-10
• Study First Posted: 2019-10-11
• Last Update Posted: 2019-10-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

1. Patient ages from 20-40 years(28).
2. Single rooted tooth with symptomatic irreversible pulpitis.
3. With no analgesic or anti-inflammatory drug taken within a week period before procedure.

Exclusion Criteria

1. Patients presenting with any systemic disease
2. Patients already taking premedication for endodontic pain.
3. Pregnant or lactating patients.
4. Multirooted teeth.
5. Teeth with Pulpal necrosis.
6. Previously treated or initiated root canal treatment.
7. Patient presenting with allergy due to drug

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Piroxicam	Piroxicam 20 mg	group 2 is given Piroxicam 20 mg half an hour before root canal treatment to manage post operative pain.
Prednisolone	prednisolone 20 mg	group 3 is given Prednisolone 20mg half an hour before root canal treatment to manage post operative pain.

Primary Outcome Measures

Name	Time	Method
post operative pain	76 hours	post operative pain will be measured after single visit endodontic treatment using visual analog scale with readings 1 to 10 from 24 hours till 76 hours

Trial Locations

Locations (1)

DUHS; 🇵🇰 Karachi, Sindh, Pakistan