Tumor Exosome Liquid Biopsy Strategy to Diagnose Pancreatic Cancer
- Conditions
- Pancreatic
- Registration Number
- NCT06108531
- Lead Sponsor
- Shanghai Jiao Tong University School of Medicine
- Brief Summary
This is an observational study of patients diagnosed with pancreatic cancer by pathology, with a control group of patients with pathology suggestive of benign pancreatic lesions and normal subjects, and the diagnostic ability of exosomes to identify patients with pancreatic cancer was assessed through the detection of exosomes in the peripheral blood.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ENROLLING_BY_INVITATION
- Sex
- All
- Target Recruitment
- 400
Diagnosis of pancreatic cancer confirmed by imaging (case) Diagnosis of chronic pancreatitis confirmed by imaging (hospital control)
The pathology diagnosis and imaging does not matched Patients with other malignant tumors Patients with other severe systemic diseases
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Characterization of proteins in tumor exosomes from patients with pancreatic cancer Up to 2 years from start of study We will select specific protein A from circulating exosomes of pancreatic cancer patients for further analysis.
The expression of protein A in the circulating exosomes from patients Up to 2 years from start of study By detecting the expression of protein A in circulating exosomes of patients. the ROC curve of A+ circulating exosomes will be compared to clinical standard tumor biomarkers (e.g., CA199) in pancreatic cancer patients.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Xinhua Hospital, Affiliated to Shanghai Jiao Tong University, School of Medicine
🇨🇳Shanghai, Shanghai, China