Neurophysiology and Anatomy of Severe Intraventricular Hemorrhage (IVH)
- Conditions
- PrematurityIntracranial Hemorrhages
- Registration Number
- NCT00817310
- Lead Sponsor
- Vanderbilt University
- Brief Summary
Currently, when premature infants develop severe intraventricular hemorrhage (IVH), a type of intracerebral bleed, there are no proven therapeutic interventions to prevent the devastating consequences of this event. These children will be likely to develop cerebral palsy or severe cognitive delays.
The purpose of our study is to characterize differences in brain physiology, imaging, and function between premature infants with severe IVH and controls. The goals for gathering this information are to generate baseline data, which could facilitate early screening for complications of IVH in premature infants. These baseline data would also allow the design and implementation of early therapeutic interventions to help rehabilitate premature infants with severe IVH.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 60
- Birth weight < 1500 grams for all inborn infants and age less than 14 post-natal days
- Birth weight < 1500 grams for all outborn infants transferred to the VCH NICU within the first 72 hours after birth and age less than 14 post-natal days
- Parents agree to their infant's participation and give informed written consent.
- Unable to obtain informed consent.
- Congenital brain malformations leading to hydrocephalus
- Genetic and metabolic disorders leading to cerebral pathology
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method neurodevelopmental outcome 3 years BSID III scores
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Monroe Carell Children's Hospital at Vanderbilt, NICU
🇺🇸Nashville, Tennessee, United States