Diode Laser-Assisted Periodontal Therapy Enhances Clinical Outcomes for Deep Periodontal Pockets in Smokers

Not Applicable

Completed

• Conditions: Periodontitis; Periodontitis Stage III; Periodontal Disease; Diode Laser Therapy; Smoking; Malondialdehyde

• Registration Number: NCT07213752
• Lead Sponsor: Selcuk University

Brief Summary

This study investigated the adjunctive effects of diode laser therapy in smokers with severe periodontitis. Thirty-three patients were randomized to non-surgical periodontal therapy (SRP) with or without diode laser. Clinical parameters and salivary oxidative stress markers (MDA, 8-OHdG) were assessed at baseline, 1, and 3 months. Both groups showed improvements, but SRP+DL resulted in significantly greater reductions in deep pockets, PISA, PESA, PI, and MDA at 3 months. These findings suggest that diode laser therapy may enhance conventional treatment by improving clinical outcomes and reducing oxidative stress in smokers with severe periodontitis.

Detailed Description

Not available

Study Timeline

• Status Verified: 2023-12
• Study Start: 2023-12-10
• Primary Completion: 2025-01-21
• Study Completion: 2025-06-05
• Study First Submitted: 2025-09-29
• Study First Submitted QC: 2025-10-02
• Last Update Submitted: 2025-10-02
• Study First Posted: 2025-10-09
• Last Update Posted: 2025-10-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 33

Inclusion Criteria

• no periodontal treatment within the previous 6 months;
• no use of antibiotics within the previous 3 months;
• no systemic disease and alcohol drinkers, or drug users;
• no use of anti-inflammatory drugs within the past 3 months;
• no pregnancy;
• no use of hormonal contraceptives; and
• current smokers with a history of smoking ≥10 cigarettes per day for at least one year.

Exclusion Criteria

• Patients with <20 teeth, grade III tooth mobility, partial dentures, or fixed prostheses were excluded. Additionally, those with dental implants or peri-implant diseases were also excluded.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Probing Pocket Dept (PPD)	Through study completion, an average of 3 months.	The probing pocket dept was assessed on six tooth surfaces, inluding the mesiobuccal, buccal, distobuccal, mesiolingual, lingual and distolingual areas of each tooth.
Periodontal Epithelial Surface Area (PESA)	Through study completion, an average of 3 months.	PESA represents the total epithelial surface area in periodontal pockets.
Periodontal Inflamed Surface Area (PISA)	Through study completion, an average of 3 months.	PISA quantifies the inflamed portion of this surface area by integrating only sites exhibiting BOP, both measured in mm2.
Salivary Malondialdehyde Levels	Through study completion, an average of 3 months.	Evaluation of salivary malondialdehyde levels.
Salivary 8-hydroxy-2'-deoxyguanosine Levels	Through study completion, an average of 3 months.	Evaluation of salivary 8-hydroxy-2'-deoxyguanosine levels.
PPD ≥4 mm, site-specific PPD (ssPPD)	Through study completion, an average of 3 months.	For sites with PPD ≥4 mm, site-specific PPD (ssPPD) values was calculated.
PPD ≥4 mm, site spesific CAL (ssCAL)	Through study completion, an average of 3 months.	For sites with PPD ≥4 mm, site spesific CAL (ssCAL) values were also calculated.
PPD ≥4 mm, site-specific PISA (ssPISA)	Through study completion, an average of 3 months.	For sites with PPD ≥4 mm, site-specific PISA (ssPISA) values were calculated.
PPD ≥4 mm, site-specific PESA (ssPESA)	Through study completion, an average of 3 months.	For sites with PPD ≥4 mm, site-specific PESA (ssPESA) values were calculated.

Secondary Outcome Measures

Name	Time	Method
Bleeding on Probing (BOP)	Through study completion, an average of 3 months.	The bleeding on probing index was assessed on six tooth surfaces, inluding the mesiobuccal, buccal, distobuccal, mesiolingual, lingual and distolingual areas of each tooth.
Clinical Attachment Level (CAL)	Through study completion, an average of 3 months.	The clinical attachment level was assessed on six tooth surfaces, inluding the mesiobuccal, buccal, distobuccal, mesiolingual, lingual and distolingual areas of each tooth.
Gingival Index (GI)	Through study completion, an average of 3 months.	The gingival index was assessed on six tooth surfaces, inluding the mesiobuccal, buccal, distobuccal, mesiolingual, lingual and distolingual areas of each tooth.
Plaque Index (PI)	Through study completion, an average of 3 months.	The plaque index was assessed on six tooth surfaces, inluding the mesiobuccal, buccal, distobuccal, mesiolingual, lingual and distolingual areas of each tooth.

Trial Locations

Locations (1)

Selcuk University Faculty of Dentistry Department of Periodontology; Konya, Selçuklu, Turkey (Türkiye)