Effects of Different Inspiratory Muscle Training Protocols in Patients With Chronic Kidney Disease
- Conditions
- Inspiratory Muscle TrainingChronic Kidney DiseasesExercise Capacity
- Interventions
- Other: Inspiratory muscle training
- Registration Number
- NCT06401135
- Lead Sponsor
- Mustafa Kemal University
- Brief Summary
The goal of this study is to investigate the effects of different IMT protocols on respiratory muscle strength, functional exercise capacity, quadriceps femoris muscle strength (QMS), handgrip muscle strength (HGS), QoL, respiratory function, dyspnoea, fatigue, balance, and PA levels in patients with CKD that were not on dialysis.
- Detailed Description
Peripheral and respiratory muscle weakness has been reported in patients with chronic kidney disease (CKD). Management of respiratory muscle weakness is crucial, as reduced functional performance is related to respiratory muscle weakness.
Different IMT function protocols with 30-70% of the maximal inspiratory pressure (MIP) have been found to improve these in patients with CKD. The most efficient IMT intensity for patients with CKD is unknown. Therefore, this study aims to investigate the effects of different IMT protocols on respiratory muscle strength, functional exercise capacity, quadriceps femoris muscle strength (QMS), handgrip muscle strength (HGS), QoL, respiratory function, dyspnoea, fatigue, balance, and PA levels in patients with CKD that were not on dialysis.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 47
- Patients with CKD stages 1-5 based on the CKD staging proposed by the Kidney Disease Outcomes Quality Initiative who are not on dialysis
- Aged>18 years
- No change in medications over one month
- Uncontrolled hypertension
- Non-stable cardiac disease
- Recent viral infections
- Respiratory, neurological, and orthopedic diseases
- Pregnant and lactating patients
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description High intensity inspiratory muscle training group Inspiratory muscle training Group 3 will receive inspiratory muscle training (IMT) using threshold loading device (POWERbreathe Classic, IMT Technologies Ltd. Birmingham, England) at 60% of maximal inspiratory pressure (MIP). The MIP will be measured at supervised session each week, and 60% of measured MIP value will be the new training workload. The treatment group will train for 30 min-per/day, 7 days/week, for 8 weeks. Six sessions at home and 1 session will be performed at department. Control group Inspiratory muscle training Group 1 will receive inspiratory muscle training (IMT) using threshold loading device (POWERbreathe Classic, IMT Technologies Ltd. Birmingham, England) at 10% of maximal inspiratory pressure (MIP). The MIP will be measured at supervised session each week, and 10% of measured MIP value will be the new training workload. The treatment group will train for 30 min-per/day, 7 days/week, for 8 weeks. Six sessions at home and 1 session will be performed at department. Low intensity inspiratory muscle training group Inspiratory muscle training Group 2 will receive inspiratory muscle training (IMT) using threshold loading device (POWERbreathe Classic, IMT Technologies Ltd. Birmingham, England) at 30% of maximal inspiratory pressure (MIP). The MIP will be measured at supervised session each week, and 30% of measured MIP value will be the new training workload. The treatment group will train for 30 min-per/day, 7 days/week, for 8 weeks. Six sessions at home and 1 session will be performed at department.
- Primary Outcome Measures
Name Time Method Inspiratory muscle strength First day A mouth pressure device will be used to evaluate IMS.
- Secondary Outcome Measures
Name Time Method Fatigue First day Fatigue will be assessed using the Fatigue Severity Scale (FSS). The total score ranges from 0 to 7.
Pulmonary functions FVC First day Spirometry will be used to assess pulmonary function.
Expiratory muscle strength First day A mouth pressure device will be used to evaluate EMS.
Dyspnoea First day Dyspnoea will be measured using the Modified Medical Research Council (MMRC) dyspnoea scale. Levels of dyspnea are graded 0-4.
Peripheral muscle strength First day A hand-held dynamometer will be used to measure peripheral muscle strength. The measurements will be repeated three times, and the highest value will be used for comparison.
Pulmonary functions FEF25-75% First day Spirometry will be used to assess pulmonary function.
Pulmonary functions FEV1 First day Spirometry will be used to assess pulmonary function.
Pulmonary functions FEV1/FVC First day Spirometry will be used to assess pulmonary function.
Functional exercise capacity First day Functional exercise capacity will be evaluated with 6 minutes working test. Test will be performed in an enclosed 30-m corridor. The patients walk as fast as they could within 6 min.
Pulmonary functions PEF First day Spirometry will be used to assess pulmonary function.
Quality of life assessment First day The Short Form 36 (SF-36) questionnaire will be used to assess QoL and includes both physical and mental components. The scores range from 0 to 100.
Physical activity First day Physical activity will be assesed using the International Physical Activity Questionnaire (IPAQ) short form, which includes questions on sitting duration, walking activity, and moderate and vigorous activities.The IPAQ is categorized as inactive (\<600 MET-min/week), minimally active (600-3000 MET-min/week), and sufficiently active (\>3000 MET-min/week) based on total scores.
Balance First day Balance will be evaluated using the Berg Balance Scale (BBS). The scale includes 14 items scoring 0 to 4. Higher scores indicate better balance.
Trial Locations
- Locations (1)
Hatay Mustafa Kemal University
🇹🇷Hatay, Turkey