Production and utilization of lactate in an intensive care patient populatio

Not Applicable

Completed

• Conditions: Mixed Intensive Care Unit patients with single or multiple organ failure; Metabolic and Endocrine - Other metabolic disorders

• Registration Number: ACTRN12617000626369
• Lead Sponsor: Karolinska University Hospital

Brief Summary

The protocol yielded results similar to those published using other protocols in healthy volunteers. ICU patients with normal lactate concentration showed similar kinetics to healthy controls. Sampling could be reduced from 43 to 14 sampled with maintained accuracy.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-05-01
• Study Completion: 2018-03-01
• Last Update Posted: 15 July 2019

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

Patients treated in the ICU who have an existing, functioning arterial and venous lines
- Informed consent to participate (can be given by next of kin when appropriate)

Exclusion Criteria

Unwillingness to participate, Unable to obtain informer consent. Terminal liver insufficiency.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Rate of appearance of lactate in blood.[Samples are taken at baseline and then throughout the first two hours after injection of 13C-lactate bolus is given. Initially every two minutes during the first hour and then every fifth minute during the second hour (t=0,2, 4, 6 .... 56, 58, 60, 65, 70...110, 115, 120)];Rate of disappearance of lactate in blood [Samples are taken at baseline and then throughout the first two hours after injection of 13C-lactate bolus is given. Initially every two minutes during the first hour and then every fifth minute during the second hour (t=0,2, 4, 6 .... 56, 58, 60, 65, 70...110, 115, 120)]

Secondary Outcome Measures

Name	Time	Method
Correlation between absolute levels of lactate in blood and rate of appearance of lactate in blood will be evaluated as a secondary outcome[Samples are taken at baseline and then throughout the first two hours after injection of 13C-lactate bolus is given. Initially every two minutes during the first hour and then every fifth minute during the second hour (t=0,2, 4, 6 .... 56, 58, 60, 65, 70...110, 115, 120)]