Changes in ocular mucin expression due to contact lens wear

Not Applicable

• Conditions: Contact lens wear affects mucin expression on the ocular surface and in tear fluid. The mucin change correlates with clinical variables and lens performance.; Eye - Normal eye development and function

• Registration Number: ACTRN12609000447257
• Lead Sponsor: Institute for Eye Research

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2009-06-12
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Stopped early
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Able to read and comprehend English and give informed consent as demonstrated by signing a record of informed consent;
Willing to comply with the wearing and clinical trial visit schedule as directed by the Investigator;
Have ocular health findings considered to be normal” and which would not prevent the participant from safely wearing contact lenses;
Has vision correctable to at least 6/12 (20/40) or better in each eye with contact lenses.

Exclusion Criteria

Regular contact lens wearers;
Pre-existing ocular irritation that would preclude contact lens fitting;
Any ocular condition that may preclude safe wearing of contact lenses e.g. active corneal infection, severe dry eye, reduced corneal sensitivity, exophthalmos/lagophthalmos, facial nerve palsy;
Active corneal infection (bacterial, viral, fungal or protozoan) or any active ocular disease such as iritis, corneal edema or corneal dystrophies, including anterior membrane dystrophy that would affect wearing of contact lenses;
Use of any of the following medications (including steroids) up to 12 weeks prior to start of the clinical trial, or during the course of the trial:
Ocular medication, category S3 and above;
Any systemic or topical medications that will affect ocular physiology or the performance of the lenses e.g. anti-acne medications such as Roaccutane and corticosteroid or immunosuppressant medications such as Hydrocortisone, Prednisolone;
Any systemic disease that may affect ocular health e.g. diabetes, Graves disease, and auto-immune diseases such as ankolysing spondylitis, multiple sclerosis, Sjogrens syndrome and systemic lupus erythematosis;
Conditions such as systemic hypertension do not automatically exclude prospective participants;
Eye surgery within 12 weeks immediately prior to enrolment for this trial;
Previous corneal refractive surgery;
Any ocular injury or condition (including keratoconus and herpes keratitis) of the cornea, conjunctiva or eyelids that would affect the wearing of contact lenses;
Contraindications to hydrogel contact lens wear;
Currently enrolled in another clinical trial;.
Be pregnant or breast feeding;*.
Allergy or intolerance to topical anaesthetics.
*verbal report of pregnancy by the participant is sufficient, formal testing not required

Study & Design

• Study Type: Interventional
• Study Design: Not specified