ACTRN12612000252819终止4 期
A Randomised Controlled trial of intravenous immunoglobulin (IVIg) compared with pulse methyl-prednisolone in Renal Transplant recipients with chronic active antibody mediated rejection to determine histological change on biopsy
Dr William Mulley0 个研究点目标入组 30 人开始时间: 2012年2月29日最近更新:
试验速览
- 阶段
- 4 期
- 状态
- 终止
- 发起方
- 入组人数
- 30
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
入排标准
- 年龄范围
- 18 Years 至 o limit（—）
- 性别
- All
入选标准
- •Renal transplant recipient
- •>6 months post-transplant
- •Biopsy evidence of cAMR defined by
- •- Activity - Peritubular capillaritis >10% and/or glomerulitis (g1 or greater)
- •- Chronic Changes - Transplant glomerulopathy or IFTA or peritubular capillary basement membrane multi-lamellation or fibrous intimal thickening of arteries.
- •Evidence of antibody activity
- •- DSAb and/or
- •- Positive C4d staining
排除标准
- •Damage to extensive
- •- IFTA >50%
- •- eGFR <25ml/min
- •- proteinuria >3gm/day
- •Too aggressive
- •- Banff PTC score =3
- •- Vascular rejection
- •Concomitant biopsy findings
- •- Recurrent or de novo GN
- •- Diabetic nephropathy
- •- Interstitial nephritis
研究者
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