The Implementation of Novel 'Heavy' Water Techniques for Determining Modulation of Muscle Protein, DNA and Lipid Synthesis Due to Ageing
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Muscle Protein Synthesis
研究概览
简要总结
Maintenance of body's skeletal muscle is key to a healthy older age. However, as we age we lose on average 1-2% of our muscle each year. In order to slow this loss we need to understand fully the mechanisms regulating muscle mass with ageing. In this project we aim to determine these mechanisms using a new novel technique of 'heavy' water ingestion, which will allow us to measure multiple aspects of skeletal muscle mass control during normal everyday activities in young and old individuals over a period of 6 weeks. We will also determine the influence of resistance exercise training during this period in offsetting declines in muscle with ageing using this method
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Young (18-30y) and old men (65-75y) who are generally healthy and recreationally active
排除标准
- •Active cardiovascular disease
- •Cerebrovascular disease including previous stroke, aneurysm (large vessel or intracranial)
- •Respiratory disease including pulmonary hypertension or COPD
- •Hyper/ hypo parathyroidism, hyper/ hypothyroidism, Cushing's disease, diabetes
- •Active inflammatory bowel disease
- •Renal disease
- •Malignancy
- •Recent steroid treatment (within 6 mo), or hormone replacement therapy
- •Clotting dysfunction
- •Musculoskeletal or neurological disorders
- •Any disease requiring long-term drug prescriptions, including statins
结局指标
主要结局
Muscle Protein Synthesis
时间窗: 0-6 Weeks
Comparison of muscle protein synthesis between young and older individuals and in response to 6 weeks unilateral exercise training
次要结局
- Muscle Sub fractions(0-6 week)