The effect of opioid-free general anesthesia on the gynecological laparoscopy

Not Applicable

Completed

• Conditions: Diseases of the genitourinary system

• Registration Number: KCT0004941
• Lead Sponsor: The Catholic University of Korea, Seoul St. Mary's Hospital

Brief Summary

Patients in dexmedetomidine group showed lower pain scores at 30 min after surgery compared to those with remifentanil (NRS; 6.1 ± 2.0 vs. 4.0 ± 1.9, P<0.001). Proportion of patients requiring rescue analgesics were significantly lower in the dexmedetomidine group (25% vs. 66.7%, P<0.001). Compared to remifentanil, dexmedetomidine did not increase time of awakening, extubation and postoperative sedation level. Dexmedetomidine also showed lower incidence of intraoperative hypotension and postoperative nausea, vomiting and shivering.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2021-03-05
• Last Update Posted: 28 November 2022

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 100

Inclusion Criteria

patient scheduled for gynecological laparoscopic surgery

Exclusion Criteria

1. patient who refuse to participate in this study
2. emergent surgery
3. chronic pain requiring for pain killer
4. psychiatric disease
5. immunologic disease (eg. SLE, Rheumatoid arthritis)
6. contraindication to dexmedetomidine: bradycardia or hypotension
7. allergy or history of the adverse effect to study drug
8. pregnancy or lactation

Study & Design

• Study Type: Interventional Study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
acute pain severity in the recovery room

Secondary Outcome Measures

Name	Time	Method
opioid associated side effects (nasea, vomiting, sedation, constipation)