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临床试验/NCT01517581
NCT01517581已完成不适用

Study on the Association Between Brown Adipose Tissue Activation and White Adipose Tissue Accumulation in Successfully Treated Pediatric Malignancy

Children's Hospital Los Angeles1 个研究点 分布在 1 个国家目标入组 32 人开始时间: 2008年10月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
32
试验地点
1
主要终点
Change from Baseline in Subcutaneous Adipose Tissue Volume at Follow-up

研究概览

简要总结

White and brown adipocytes differ in their expression of hormones, cytokines, and inflammatory factors, and they modulate different biological functions. While white adipose tissue (WAT) serves as the primary site of energy storage, brown adipose tissue (BAT) instead metabolizes fat to produce heat and regulate body temperature. BAT is likely present in all humans, but the low prevalence of BAT depiction in adults and elderly subjects has hindered longitudinal assessments of the relation between BAT activity and WAT. Under typical imaging conditions, BAT is detected more frequently in children and teenagers than in adults with malignancy. Since most children with cancer have significantly shorter treatment courses and greater survival rates compared to adult patients, the investigators have the ability to examine the relation of repeated measures of body composition and BAT by selecting pediatric patients. In this study, the investigators will longitudinally examine whether BAT activity is related to changes in weight and the amounts of SAT, VAT, and abdominal muscle in children successfully treated for pediatric cancer.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Retrospective

入排标准

年龄范围
6 Years 至 18 Years(Child, Adult)
性别
All
接受健康志愿者

入选标准

  • Patients had PET/CT scans with evidence of malignant disease
  • Patients had no metabolically active BAT at diagnosis on their PET/CT scan
  • Patients were disease free within 1 year of diagnosis

排除标准

  • Patients had PET/CT scans with no evidence of malignant disease
  • Patients with metabolically active BAT at diagnosis on their PET/CT scan
  • Patients were not disease free within 1 year of diagnosis

结局指标

主要结局

Change from Baseline in Subcutaneous Adipose Tissue Volume at Follow-up

时间窗: Baseline and up to 1 year

Change from Baseline in Visceral Adipose Tissue Volume at Follow-up

时间窗: Baseline and up to 1 year

Change from Baseline in Presence of Brown Adipose Tissue

时间窗: Baseline and up to 1 year

Change from Baseline in Abdominal Musculature Volume

时间窗: Baseline and up to 1 year

次要结局

  • Change from Baseline in Anthropometric Measures at Follow-up(Baseline and up to 1 year)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Vicente Gilsanz

Professor

Children's Hospital Los Angeles

研究点 (1)

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