Investigation of the Impact of Degree of Weight Loss on Physiological Adaptations to Weight Loss
Not Applicable
Active, not recruiting
- Conditions
- ObesityDiet and Nutrition - Obesity
- Registration Number
- ACTRN12614000141640
- Lead Sponsor
- niversity of Melbourne
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Active, not recruiting
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
*Written informed consent obtained
*Age 18 – 65 years
*BMI 25-50kg/m2
*Stable body weight
*In good health
Exclusion Criteria
*Body builders
*Significant illness
*History of recent weight loss
*Past history of bariatric surgery
*Use of weight affecting pharmacotherapy
*Current smokers
*History of unstable thyroid disorder
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Degree of reduction in body weight required to bring about compensatory mechanisms (assessed using weight measurements via calibrated scales, measurements of gut hormones (amylin, PYY, GLP-1, leptin ,ghrelin, GIP,PP and INSL5)glucose, insulin and free fatty acids via serum assays) [12 weeks];To investigate if body weight is equally regulated across a range of BMIs (assessed using weight measurements via calibrated scales, measurements of gut hormones (amylin, PYY, GLP-1, leptin ,ghrelin, GIP,PP and INSL5)glucose, insulin and free fatty acids via serum assays) [week 64]
- Secondary Outcome Measures
Name Time Method Degree of weight regain from week 13-64 (assessed via weight measurements using calibrated scales)[week 64];Change from baseline to week 12; and week 13-64 in gut hormone measurements, fasting glucose measurement, fasting insulin measurement and appetite (as measured by visual analogue scale)(assessed using weight measurements via calibrated scales, measurements of gut hormones (amylin, PYY, GLP-1, leptin ,ghrelin, GIP,PP and INSL5)glucose, insulin and free fatty acids via serum assays) [week 64]