Using Circulating Tumor Cells to Diagnose and Predict Prognosis in Metastatic Nasopharyngeal Carcinoma Patients

Sun Yat-sen University0 sites166 target enrollmentDecember 2014

ConditionsNasopharyngeal Neoplasms

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Nasopharyngeal Neoplasms
Sponsor: Sun Yat-sen University
Enrollment: 166
Primary Endpoint: Overall survival rate
Status: Completed
Last Updated: 9 years ago

Overview Investigators Eligibility Criteria Outcomes Similar Trials

Overview

Brief Summary

A circulating tumor cell (CTC) count is an established prognostic factor in some malignancies such as metastatic breast cancer. However, the value of CTC in diagnosis and outcome prediction of metastatic nasopharyngeal carcinoma (mNPC) patients is not unknown. Through the observational prospective clinical trial, sensitivity, specificity, positive and negative predictive values of CTC in diagnosis of mNPC patients will be gained. Further, the value of CTC in outcome prediction of mNPC patients will be uncovered.

Registry

clinicaltrials.gov

Start Date

December 2014

End Date

August 2016

Last Updated

9 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

Sun Yat-sen University

Responsible Party

Principal Investigator

Ming-Yuan Chen

Prof.

Sun Yat-sen University

Eligibility Criteria

Inclusion Criteria

•Histologically or radiologically confirmed nasopharyngeal non-keratinizing carcinoma (WHO II, III).
•NPC patients with distant metastasis including synchronous distant metastasis at diagnosis and metachronous distant metastasis after radical treatment.
•A Karnofsky performance status score more than
•The participants provided written informed consent.

Exclusion Criteria

•A history of previous or synchronous malignant tumors.
•Suffering from severe mental illness synchronously.
•Suffering from severe heart or lung diseases.
•Obvious abnormality in liver and renal function.
•Women in pregnancy or breastfeeding.

Outcomes

Primary Outcomes

Overall survival rate

Time Frame: 3 years

Secondary Outcomes

The proportions of positive results in statistics and diagnostic tests that are true positive results.(3 years)
The proportions of negative results in statistics and diagnostic tests that are true negative results.(3 years)
The proportion of positives that are correctly identified as such(3 years)
The proportion of negatives that are correctly identified as such(3 years)