Body Composition Study in Critically Ill Patients-Extended to COVID-19
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 59
- 试验地点
- 2
- 主要终点
- Rectus Femoris Cross-sectional Area
研究概览
简要总结
Muscle loss (ultrasound quadricep muscle) and muscle strength (handgrip and knee extension strength) will be compared between COVID-19 and non COVID-19 critically ill patients.
详细描述
Given the heightened inflammatory status among COVID-19 critically ill patients, we hypothesized that the rate of skeletal muscle loss is accelerated in this population, and this loss is even more pronounce than the general critically ill patients. We further hypothesized that the increased muscle loss will lead to worse functional outcome (lower muscle strength) in COVID-19 critically ill patients compared with age- and sex-matched non-COVID-19 critically ill patients, as it has been shown that quadriceps thickness is strongly correlated with functional status at ICU discharge. Furthermore, a recent systematic review and meta-analysis in survivors of coronavirus (severe acute respiratory syndrome, SARS or Middle-east respiratory syndrome, MERS, or COVID-19) also demonstrated reduced exercise capacity and quality of life at 6 months after hospitalization or ICU admission
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •≥ 18 years old
- •Admitted into the ICU due to COVID-19
排除标准
- •Likely to transfer out from the ICU in 24 hours from screening
- •Likely to die in the next 7 days
- •Bedbound prior to hospital admission or bedbound in the hospital for >10 days
研究组 & 干预措施
ICU COVID-19 patients
COVID-19 patients that are admitted into the ICU and fulfilled the eligibility criteria
干预措施: No Intervention (Other)
ICU non-COVID-19 patients
Non-COVID-19 patients that are admitted into the ICU matched with ICU COVID-19 patients that are recruited and fulfilled the eligibility criteria
干预措施: No Intervention (Other)
结局指标
主要结局
Rectus Femoris Cross-sectional Area
时间窗: Change in Rectus Femoris Cross-sectional Area at day 7 or ICU discharge or hospital discharge compared with baseline (Day 1 of ICU admission)
Change in Rectus Femoris Cross-sectional Area
Rectus Femoris Thickness
时间窗: Change in Rectus Femoris Thickness at day 7 or ICU discharge or hospital discharge compared with baseline (Day 1 of ICU admission)
Change in Rectus Femoris Thickness
次要结局
- Forearm Muscle Thickness(Change in Forearm Muscle Thickness at day 7 or ICU discharge or hospital discharge compared with baseline (Day 1 of ICU admission))
- Handgrip Strength(Before Hospital Discharge)
- Knee Extension Strength(Before Hospital Discharge)