Comparison of Multifocal Electroretinogram Assessment in Chronic Central Serous Chorioretinopathy (CSC) Between Laser Treatment Group and Photodynamic Therapy Group in Chronic Central Serous Chorioretinopathy

Completed

Brief Summary: This study is a comparison of multifocal electroretinogram assessment between the laser treatment group and the photodynamic therapy group in chronic central serous chorioretinopathy.

Detailed Description: 1. Laser Group: extrafoveal focal leakage on FAG

2. PDT Group: no definite focal leak on FAG subfoveal or juxtafoveal focal leakage on FAG, or serous retinal pigmentary epithelial detachment involving foveal center

Inclusion criteria

1. Chronic serous chorioretinopathy (over 3 months) when subretinal fluid persisted in the subfoveal region demonstrated by clinical examination and OCT

2. Ability to maintain steady fixation for mfERG

3. Presence of abnormal dilated choroidal vasculature in ICGA

4. Symptom duration over 3 months

Exclusion criteria

1. previous PDT or laser treatment history

2. evidence of Choriinal neovascularization in FAG

3. other chorioretinal disorders that can cause macular exudation such as age-related macular degeneration, pathologic myopia, angioid streaks, trauma, inflammatory diseases, retinal vasculopathies, and hereditary dystrophies

follow-up Visit

1)baseline 2)1month 3)3months 4)6 months

each visit: multifocal electroretinogram, visual acuity, optical coference timography should be measured.

Recruitment & Eligibility

Inclusion Criteria

CSC (over 3 months) when subretinal fluid persisted in the subfoveal region demonstrated by clinical examination and OCT
Ability to maintain steady fixation for mfERG
Presence of abnormal dilated choroidal vasculature in ICGA
Symptom duration over 3 months

Exclusion Criteria

Previous PDT or laser treatment history
Evidence of CNV in FAG
Other chorioretinal disorders that can cause macular exudation such as age-related macular degeneration, pathologic myopia, angioid streaks, trauma, inflammatory diseases, retinal vasculopathies, and hereditary dystrophies

Primary Outcome Measures

Name	Time	Method
Multifocal Electroretinogram Amplitudes	baseline, 1 month, 3 months, 6 months	Amplitude at first annular ring at multifocal electroretinogram RETIscan (Roland Consult, Wiesbaden, Germany) is used for multifocal retinogram. The recording protocol was chosen according to the International Society for Clinical Electro-physiology of Vision (ISCEV) guidelines.

Secondary Outcome Measures

Name	Time	Method
Best Corrected Visual Acuity	baseline, 1 month, 3 months, 6 months	Best-corrected visual acuities were obtained with Snellen charts. Snellen's visual acuity was converted logarithm of the minimum angle of resolution (logMAR) for statistical analysis.