Circadian Rhythm In Tobramycin Elimination in Cystic Fibrosis (CRITIC) - a Randomised Pharmacokinetic Comparison of Tobramycin in CF - Circadian Rhythm In Tobramycin Elimination in Cystic Fibrosis CRITIC-1

The Univeristy of Nottingham0 个研究点目标入组 20 人开始时间: 2010年11月23日最近更新: 2019年12月10日

适应症

试验速览

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•i) Diagnosis of CF (defined as clinical features of CF plus a positive sweat test OR the presence of 2 genes known to be associated with CF disease. ii) Infection with P. aeruginosa (chronic or intermittent) iii) Patient or parent / legal guardian able to give informed consent
•Are the trial subjects under 18? yes
•Number of subjects for this age range: 0
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 0
•F.1.3 Elderly (>=65 years) no
•F.1.3.1 Number of subjects for this age range 0

•i) Previous episode of acute kidney injury ii) Solid organ transplantation iii) Evidence of impaired renal function (raised serum creatinine above the normal range for age) iv) Once daily aminoglycoside unsuitable because of hypersensitivity or previous high trough levels on once daily dosing. v) Pregnancy

发起方

The Univeristy of Nottingham