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临床试验/NCT03473678
NCT03473678已完成不适用

Influence of Dietary Nitrate Supplementation on Blood Pressure, Walking Economy, Functional Physical Capacity and Cognitive Function in Healthy Older Adults

University of Exeter1 个研究点 分布在 1 个国家目标入组 30 人开始时间: 2014年2月12日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
入组人数
30
试验地点
1
主要终点
Blood pressure

研究概览

简要总结

This study investigates the influence of dietary nitrate supplementation on cardiovascular health and physical and cognitive performance in older adults. Participants will receive both a nitrate containing beetroot juice for 10 days and a nitrate depleted beetroot juice for 10 days

详细描述

A recent exciting finding is that dietary nitrate supplementation (in the form of beetroot juice) appears to reduce the amount of oxygen needed to complete moderate intensity walking in healthy, young individuals. Nitrate is known to be converted in the body to nitric oxide (NO), a substance which reduces blood pressure and may affect the energy-producing mechanisms inside muscle cells. Exercise tolerance and muscle function typically declines with age and nitrate supplementation therefore may help improve cardiovascular health and the ability to carry out low-intensity daily activities in aging populations. The purpose of this study is to see if healthy, elderly individuals benefit from beetroot juice intake similarly to the effects seen in young adults. If this is indeed the case, then it may suggest that dietary supplementation with a relatively cheap, widely available, and natural food product may improve the ability of healthy elderly individuals to undergo everyday tasks and ultimately improve their quality of life.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Crossover
主要目的
Other
盲法
Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)

入排标准

年龄范围
70 Years 至 80 Years(Older Adult)
性别
All
接受健康志愿者
是

入选标准

  • •70 - 80 years of age
  • •male or female

排除标准

  • •involved in regular structured exercise
  • •receiving medication for:
  • •pulmonary conditions
  • •cardiovascular conditions
  • •metabolic conditions
  • •musculoskeletal conditions
  • •ulcerative colitis
  • •renal disease

研究组 & 干预措施

Nitrate-rich beetroot juice

Active Comparator

2 x 70mL concentrated juice per day for 10 days

干预措施: Nitrate-rich beetroot juice (Dietary Supplement)

Nitrate-depleted beetroot juice

Placebo Comparator

2 x 70mL concentrated juice per day for 10 days

干预措施: Nitrate-depleted beetroot juice (Dietary Supplement)

结局指标

主要结局

Blood pressure

时间窗: 10 days

Change in blood pressure between interventions

次要结局

  • 6 minute walk test(10 days)
  • Oxygen cost of exercise(10 days)
  • Serial Subtraction test(10 days)
  • Brain metabolism(10 days)
  • Microbiome(10 days)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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