Influence of Dietary Nitrate Supplementation on Blood Pressure, Walking Economy, Functional Physical Capacity and Cognitive Function in Healthy Older Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Blood pressure
研究概览
简要总结
This study investigates the influence of dietary nitrate supplementation on cardiovascular health and physical and cognitive performance in older adults. Participants will receive both a nitrate containing beetroot juice for 10 days and a nitrate depleted beetroot juice for 10 days
详细描述
A recent exciting finding is that dietary nitrate supplementation (in the form of beetroot juice) appears to reduce the amount of oxygen needed to complete moderate intensity walking in healthy, young individuals. Nitrate is known to be converted in the body to nitric oxide (NO), a substance which reduces blood pressure and may affect the energy-producing mechanisms inside muscle cells. Exercise tolerance and muscle function typically declines with age and nitrate supplementation therefore may help improve cardiovascular health and the ability to carry out low-intensity daily activities in aging populations. The purpose of this study is to see if healthy, elderly individuals benefit from beetroot juice intake similarly to the effects seen in young adults. If this is indeed the case, then it may suggest that dietary supplementation with a relatively cheap, widely available, and natural food product may improve the ability of healthy elderly individuals to undergo everyday tasks and ultimately improve their quality of life.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 70 Years 至 80 Years(Older Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •70 - 80 years of age
- •male or female
排除标准
- •involved in regular structured exercise
- •receiving medication for:
- •pulmonary conditions
- •cardiovascular conditions
- •metabolic conditions
- •musculoskeletal conditions
- •ulcerative colitis
- •renal disease
研究组 & 干预措施
Nitrate-rich beetroot juice
2 x 70mL concentrated juice per day for 10 days
干预措施: Nitrate-rich beetroot juice (Dietary Supplement)
Nitrate-depleted beetroot juice
2 x 70mL concentrated juice per day for 10 days
干预措施: Nitrate-depleted beetroot juice (Dietary Supplement)
结局指标
主要结局
Blood pressure
时间窗: 10 days
Change in blood pressure between interventions
次要结局
- 6 minute walk test(10 days)
- Oxygen cost of exercise(10 days)
- Serial Subtraction test(10 days)
- Brain metabolism(10 days)
- Microbiome(10 days)
