Brown Adipose Tissue in Type 1 Diabetes
Not Applicable
Completed
- Conditions
- Type1diabetes
- Registration Number
- NCT02984514
- Lead Sponsor
- Per-Ola Carlsson
- Brief Summary
Brown adipose tissue has the capacity to consume large amounts of energy and has insulin-independent glucose uptake. The investigators have recently observed an inverse correlation between irisin levels and insulin needs of type 1 diabetes patients. Transplantation of brown adipose tissue to insulin-deficient rats normalized their blood glucose levels.
In this study 12 patients with long-standing type 1 diabetes (\>10 years) and with variable exogenous insulin needs will be investigated for amount of brown adipose tissue with positron emission tomography using the tracer 18F-deoxy glucose.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 11
Inclusion Criteria
- Adult patients (18 years of age or more)
- Type 1 diabetes diagnose for more than 10 years
Exclusion Criteria
- Ongoing pregnancy
- Ongoing breast-feeding
- BMI<19
- BMI >30
- P-creatinine <110 µmol/l
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Activity of brown adipose tissue in correlation to exogenous insulin needs using the tracer 18F-deoxy glucose in positron emission tomography measurements Assessment performed after more than 10 years of diagnosed type 1 diabetes
- Secondary Outcome Measures
Name Time Method Glucose uptake in muscle in correlation to exogenous insulin needs; assessment using the tracer 18F deoxy glucose in positron emission tomography measurements. Assessment performed after more than 10 years of diagnosed type 1 diabetes
Trial Locations
- Locations (1)
Uppsala University Hospital
🇸🇪Uppsala, Sweden
Uppsala University Hospital🇸🇪Uppsala, Sweden