Effect of the Intensity of Continuous Renal Replacement Therapy
- Conditions
- Optimal Intensity of Renal Replacement Therapy on Sepsis Patients
- Interventions
- Other: extra high volume hemofiltrationOther: high volume hemofiltration
- Registration Number
- NCT01251081
- Lead Sponsor
- Zhejiang University
- Brief Summary
In patients with sepsis and AKI, increasing the intensity of renal replacement therapy from 50 mL/kg/h (HVHF) to 85 mL/kg/h (EHVHF)will increase the survival at 28 days and 90 days.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 280
met at least one of the following criteria: oliguria (urine output less than 100 mL in a 6 h period and unresponsive to fluid resuscitation), serum potassium concentration more than 6.5 mmol/L, severe acidemia (pH < 7.2), serum creatinine more than 250 µmol/L, or presence of severe organ edema (e.g. pulmonary edema).
- were presence of a malignant tumor, chronic renal insufficiency (serum creatinine >133 µmol/L), or receiving any kind of renal replacement therapy before randomization.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description extra high volume hemofiltration extra high volume hemofiltration extra high volume hemofiltration (85 mL/kg/h, EHVHF) high volume hemofiltration high volume hemofiltration high volume hemofiltration (50 mL/kg/h, HVHF)
- Primary Outcome Measures
Name Time Method 90 days survival The primary study outcome was death from any cause within 90 days. Results were analyzed by Kaplan-Meier survival curves
- Secondary Outcome Measures
Name Time Method length of stay in the ICU and hospital Secondary outcomes were length of stay in the ICU and hospital and renal outcome of survivors at 90 days after randomization.
Trial Locations
- Locations (1)
Kidney disease center, the first affiliated hospital, medical college of Zhejiang university
🇨🇳Hangzhou, Zhejiang, China