ACTRN12622000436774招募中未知
A multi-centre, prospective, non-randomised implementation study of incorporating a polygenic risk score into cardiovascular disease Examinations to identify SubClinicAL coronAry arTEry disease (The ESCALATE Study)
适应症
试验速览
- 阶段
- 未知
- 状态
- 招募中
- 入组人数
- 1,000
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Non-randomised trial
- 主要目的
- Diagnosis
入排标准
- 年龄范围
- 45 Years 至 65 Years（—）
- 性别
- All
入选标准
- •Males aged 45 to 60 years old
- •- Females aged 50 to 65 years old
- •- Eligible for a Medicare rebated cardiovascular disease consultation with a GP, including Heart Health Check MBS Item Numbers 177 or 699
- •- Willingness to undergo the PRS and/or CACS interventions as indicated per the PPP-CAD clinical pathway
- •- At least one (1) prior clinical visit to the GP
- •- Willing and able to provide informed consent by self
排除标准
- •- Conditions placing the individual at clinically determined high risk of CVD, not requiring calculation of Absolute CVD Risk:
- •- Diabetes and age greater than 60 years
- •-Diabetes with microalbuminuria (greater than 20 mcg/min or UACR greater than 2.5 mg/mmol for males, greater than 3.5 mg/mmol for females)
- •- Moderate or severe chronic kidney disease (CKD) (persistent proteinuria or eGFR less than 45mL/min/1.73m2)
- •- Previous diagnosis of familial hypercholesterolaemia
- •- Systolic blood pressure (SBP) greater than or equal to 180mmHg or diastolic blood pressure (DBP) greater than or equal to 110mmHg
- •- Serum total cholesterol greater than 7.5mmol/L
- •- Symptomatic or previously documented CAD
- •- Previous CVD event, including angina, myocardial infarction (MI), percutaneous coronary intervention, coronary artery bypass grafting, ischaemic stroke, transient ischaemic attack, heart failure, or peripheral arterial disease.
- •- Prior mediastinal radiation exposure or therapy
- •- Prior medical diagnosis of rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE)
- •- Patients highly dependent on medical care and unable to provide informed consent
- •- Unable or unwilling to participate in 12-month follow-up
- •- People with cognitive impairment, intellectual disability, or mental illness that prevent them from providing informed consent for themselves.
研究者
相似试验
已完成
不适用
Safety and efficacy of the Misago® peripheral self-expanding stent system in real-world patientsISRCTN57930977Terumo Europe N.V. (Belgium)2,000
已完成
不适用
Prospective, non-randomised, multi-centre, observational study to confirm the performance of Misago® peripheral self-expanding stent system for the treatment of occluded or stenotic superficial femoral or popliteal arteriesOccluded or stenotic superficial femoral and/or popliteal arteriesCirculatory SystemArterial embolism and thrombosisISRCTN58138617Terumo Europe N.V. (Belgium)500
招募中
不适用
A multi-center, pivotal, non-randomized, prospective, open-label study to evaluate the safety and performance of the Hy2Care Injectable Hydrogel for the repair of cartilage defects in the knee.Cartilage defectcartilage lesion1004323710005944NL-OMON50832Hy2Care B.V.46
招募中
Unknown
To evaluate the effect of Remogliflozin 100 mg or Dapagliflozin 10 mg adding to standard of care treatment for Type II Diabetes patients having chronic kidney diseaseCTRI/2023/03/050384Prof Dr Hemant Gupta
尚未招募
不适用
A study to evaluate the performance of a pedicle screw system for correction and fusion of Adolescent Idiopathic ScoliosisAdolescent idiopathic scoliosisMusculoskeletal - Other muscular and skeletal disordersSurgery - Other surgeryACTRN12612000316808Kspine20