The Effects of Ozone Therapy as an Adjunct to Periodontal Treatment: A Randomized Split-Mouth Clinical Trial
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Periodontitis
- Sponsor
- TC Erciyes University
- Enrollment
- 20
- Primary Endpoint
- Periodontal disease parameters change
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
This randomized, placebo controlled, split-mouth clinical study trial evaluates the effects of Ozone therapy on clinical and biochemical parameters. Total of 20 participants completed the study . Periodontal parameters were evaluated at baseline and 3 months following periodontal therapy. All participants were treated non-surgically. Topical gaseous ozone was applied into periodontal pockets. Gingival crevicular fluid pentraxin-3 (PTX-3), interleukin-1β (IL-1β) and high sensitivity C-reactive protein (Hs-CRP) were evaluated.
Detailed Description
Ozone therapy (OT) is very popular in medicine. Especially it use for wound healing and antibacterial properties. This randomized, placebo controlled, randomized split-mouth clinical study evaluates the effects of ozone therapy on clinical and biochemical parameters. Total of 20 participants completed the study (10 males, 10 females). Periodontal parameters, including plaque index (PI), gingival index (GI), probing depth (PD), percentage of bleeding on probing, percentage of pockets deeper than 5 mm and clinical attachment level (CAL), and percentage of ≥3 mm clinical attachment level. Periodontal parameters were evaluated at baseline and 3 months following periodontal therapy. All participants were treated non-surgically. Topical gaseous ozone was applied into periodontal pockets twice a week for 2 weeks during active periodontal therapy. Gingival crevicular fluid pentraxin-3 (PTX-3), interleukin-1β (IL-1β) and high sensitivity C-reactive protein (Hs-CRP) were evaluated.
Investigators
Zekeriya Tasdemir
Principal investigator
TC Erciyes University
Eligibility Criteria
Inclusion Criteria
- •18 to 64 years of age
- •Generalized chronic periodontitis(Armitage, 1999)
- •Systemically healthy
- •More than 20 teeth (excluding third molars)
Exclusion Criteria
- •Periodontal treatment within 6 months
- •Antibiotic use within the previous 3 months
- •Pregnancy and lactation
- •Past or current smoking and alcohol consumption
- •Contraindications for OT
- •Patients with class II and III furcation defects(Staffileno, 1969)
Outcomes
Primary Outcomes
Periodontal disease parameters change
Time Frame: Examinations were performed at baseline and 3 months after periodontal therapy. Changes is determined with baseline values - 3 months after periodontal treatment.
Probing depth (mm) were evaluated by periodontal probe.
Secondary Outcomes
- Gingival crevicular inflammatory parameter change(inflammatory biochemical parameters were analyzed at baseline and 3 months after periodontal therapy and changes is determined with baseline values - 3 months after periodontal therapy.)