Comparative Investigation of Low Molecular Weight (LMW) Heparin/Edoxaban Tosylate (DU176b) Versus (LMW) Heparin/Warfarin in the Treatment of Symptomatic Deep-Vein Blood Clots and/or Lung Blood Clots. (The Edoxaban Hokusai-VTE Study).
- Conditions
- Pulmonary Embolism (PE)Venous ThromboembolismThromboembolismDeep Vein Thrombosis (DVT)Venous Thrombosis
- Interventions
- Drug: low molecular weight heparin/unfractionated heparin
- Registration Number
- NCT00986154
- Lead Sponsor
- Daiichi Sankyo
- Brief Summary
Evaluation of heparin/edoxaban tosylate (DU176b) versus heparin/warfarin in preventing recurrence of blood clots in patients with acute symptomatic deep-vein blood clots in the legs and/or blood clots in the lungs.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 8292
- Male or female subjects older than the minimum legal adult age (country specific);
- Acute symptomatic proximal DVT and/or symptomatic PE confirmed at the site by appropriate diagnostic imaging;
- Able to provide written informed consent
- thrombectomy, insertion of a caval filter, or use of a fibrinolytic agent to treat the current episode of DVT and/or PE;
- More than 48 hours pre-treatment with anticoagulant therapy prior to randomization;
- Calculated Creatinine clearance (CrCL) < 30 mL/min;
- significant liver disease (e.g., acute hepatitis, chronic active hepatitis, cirrhosis) or alanine transaminase (ALT) >\= 2 times the upper limit of normal (ULN), or total bilirubin (TBL) x 1.5 times the ULN;
- patients with active cancer for whom long term treatment with (LMW) heparin is anticipated;
- active bleeding or high risk for bleeding contraindicating treatment with (LMW) heparin or warfarin;
- chronic treatment with non-aspirin non-steroidal anti-inflammatory drugs (NSAIDs);
- treatment with aspirin in a dosage of more than 100 mg/per day or dual antiplatelet therapy;
- concurrent treatment with potent P-gp inhibitors;
- subjects with any condition that, as judged by the investigator, would place the subject at increased risk of harm if he/she participated in the study
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description heparin/edoxaban tosylate edoxaban tosylate(DU-176b) - heparin/edoxaban tosylate low molecular weight heparin/unfractionated heparin - heparin/warfarin low molecular weight heparin/unfractionated heparin - heparin/warfarin warfarin -
- Primary Outcome Measures
Name Time Method Symptomatic Recurrent VTE, i.e., the Composite of DVT, Non-fatal PE, and Fatal PE 12 months from time of randomization Symptomatic recurrent Venous Thromboembolism (VTE), i.e., the composite of deep Vein Thrombosis (DVT), non-fatal Pulmonary Embolism (PE), and fatal PE occurring during the Overall Study Period.
Overall Study Period defined as "The time from the reference date (randomization date/initial dose of study drug date) to the last study follow-up visit."
- Secondary Outcome Measures
Name Time Method Clinically Relevant Bleeding (i.e., Major or Clinically Relevant Non-major Bleeding) Occurring During Treatment 12 months from time of randomization Clinically relevant bleeding (i.e., major or clinically relevant non-major bleeding) occurring during treatment plus 3 days after their last dose for that time period.
The Composite Clinical Outcome of Symptomatic Recurrent VTE and All-cause Mortality 12 months from time of randomization
Trial Locations
- Locations (405)
Investigational Site 1602
🇧🇪Lier, Belgium
Investigational Site 2803
🇦🇹Graz, Austria
Investigational Site 2800
🇦🇹Innsbruck, Austria
Investigational Site 2703
🇧🇾Gomel, Belarus
Investigational Site 2702
🇧🇾Minsk, Belarus
Investigational Site 2705
🇧🇾Mogilev, Belarus
Investigational Site 2704
🇧🇾Grodno, Belarus
Investigational site 2701
🇧🇾Minsk, Belarus
Investigational Site 1608
🇧🇪Aalst, Belgium
Investigational Site 2006
🇨🇦Edmonton, Alberta, Canada
Investigational Site 2101
🇪🇪Tallinn, Estonia
Investigational Site 5413
🇭🇺Baja, Hungary
Investigational Site 5410
🇭🇺Pecs, Hungary
Investigational Site 4459
🇮🇳Bangalore, India
Investigational Site 4420
🇮🇳Lucknow, India
Investigational Site 5407
🇭🇺Miskolc, Hungary
Investigational Site 4402
🇮🇳Bangalore, India
Investigational Site 4451
🇮🇳Hyderabad, India
Investigational Site 4425
🇮🇳Pune, India
Investigational Site 4442
🇮🇳Bangalore, India
Investigational Site 4472
🇮🇳Bangalore, India
Investigational Site 4407
🇮🇳Hyderabad, India
Investigational Site 4444
🇮🇳Hyderabad, India
Investigational Site 4409
🇮🇳Mumbai, India
Investigational Site 4424
🇮🇳Mumbai, India
Investigational Site 4419
🇮🇳New Delhi, India
Investigational Site 4441
🇮🇳New Delhi, India
Investigational Site 4443
🇮🇳Pune, India
Investigational Site 4462
🇮🇳Pune, India
Investigational Site 4470
🇮🇳Secunderbad, India
Investigational Site 5506
🇮🇱Haifa, Israel
Investigational Site 5500
🇮🇱Holon, Israel
Investigational Site 5501
🇮🇱Jerusalem, Israel
Investigational Site 5510
🇮🇱Petah-Tikva, Israel
Investigational Site 5505
🇮🇱Kfar Saba, Israel
Investigational Site 5512
🇮🇱Poriya, Israel
Investigational Site 5503
🇮🇱Tel Aviv, Israel
Investigational Site 5509
🇮🇱Tel Hashomer, Israel
Investigational Site 6150
🇯🇵Hiroshima, Japan
Investigational Site 6137
🇯🇵Aichi, Japan
Investigational Site 6104
🇯🇵Aomori, Japan
Investigational Site 6117
🇯🇵Chiba, Japan
Investigational Site 6119
🇯🇵Fukuoka, Japan
Investigational Site 6110
🇯🇵Fukushima, Japan
Investigational Site 6138
🇯🇵Hokkaido, Japan
Investigational Site 6141
🇯🇵Hokkaido, Japan
Investigational Site 6133
🇯🇵Hyogo, Japan
Investigational Site 6114
🇯🇵Ishikawa, Japan
Investigational Site 6144
🇯🇵Kagoshima, Japan
Investigational Site 6112
🇯🇵Kanagawa, Japan
Investigational Site 6123
🇯🇵Kumamoto, Japan
Investigational Site 6147
🇯🇵Kumamoto, Japan
Investigational Site 6148
🇯🇵Kumamoto, Japan
Investigational Site 6129
🇯🇵Mie, Japan
Investigational Site 6139
🇯🇵Nagasaki, Japan
Investigational Site 6107
🇯🇵Niigata, Japan
Investigational Site 6152
🇯🇵Okayama, Japan
Investigational Site 6132
🇯🇵Osaka, Japan
Investigational Site 6130
🇯🇵Sapporo, Japan
Investigational Site 6143
🇯🇵Shizuoka, Japan
Investigational Site 6102
🇯🇵Tokyo, Japan
Investigational Site 6105
🇯🇵Tokyo, Japan
Investigational Site 6113
🇯🇵Tokyo, Japan
Investigational Site 6142
🇯🇵Tokyo, Japan
Investigational Site 6145
🇯🇵Tokyo, Japan
Investigational Site 6149
🇯🇵Tottori, Japan
Investigational Site 1303
🇲🇽Zapopan, Jalisco, Mexico
Investigational Site 1302
🇲🇽Monterrey, Nuevo Leon, Mexico
Investigational Site 1304
🇲🇽Guadalajara, Mexico
Investigational Site 1300
🇲🇽Hermosillo, Mexico
Investigational Site 3608
🇳🇱Alkmaar, Netherlands
Investigational Site 3602
🇳🇱Nijmegen, Netherlands
Investigational Site 5018
🇵🇱Tarnow, Poland
Investigational Site 4100
🇨🇭Luzern, Switzerland
Investigational Site 5104
🇨🇳Kaohsiung, Taiwan
Investigational Site 5105
🇨🇳Taichung, Taiwan
Investigational Site 5101
🇨🇳Taipei, Taiwan
Investigational Site 5200
🇹🇭Bangkok, Thailand
Investigational Site 5202
🇹🇭Bangkok, Thailand
Investigational Site 4008
🇺🇦Dnipropetrovsk, Ukraine
Investigational Site 4000
🇺🇦Ivano-Frankivsk, Ukraine
Investigational Site 4001
🇺🇦Kiev, Ukraine
Investigational Site 4009
🇺🇦Uzhgorod, Ukraine
Investigational Site 4003
🇺🇦Vinnitsya, Ukraine
Investigational Site 1032
🇺🇸Greenville, South Carolina, United States
Investigational Site 1034
🇺🇸Greenville, South Carolina, United States
Investigational Site 1100
🇦🇷Buenos Aires, Argentina
Investigational Site 1104
🇦🇷Cordoba, Argentina
Investigational Site 1110
🇦🇷Pcia De Corrientes, Argentina
Investigational Site 2804
🇦🇹Linz, Austria
Investigational Site 1109
🇦🇷Santa Fe, Argentina
Investigational Site 3302
🇫🇷Amiens, France
Investigational Site 3300
🇫🇷Arras, France
Investigational Site 1706
🇩🇪Tubingen, Germany
Investigational Site 7127
🇺🇸Saint Petersburg, Florida, United States
Investigational Site 1076
🇺🇸Tacoma, Washington, United States
Investigational Site 1042
🇺🇸Tyler, Texas, United States
Investigational Site 7105
🇺🇸Fort Worth, Texas, United States
Investigational Site 1037
🇺🇸Westminster, Maryland, United States
Investigational Site 7104
🇺🇸Albany, Georgia, United States
Investigational Site 1065
🇺🇸Covington, Louisiana, United States
Investigational Site 1038
🇺🇸Westminster, Maryland, United States
Investigational Site 7122
🇺🇸Toledo, Ohio, United States
Investigational Site 7152
🇺🇸Bend, Oregon, United States
Investigational Site 7109
🇺🇸Lancaster, Pennsylvania, United States
Investigational Site 1106
🇦🇷Buenos Aires, Argentina
Investigational Site 7106
🇺🇸Gainesville, Florida, United States
Investigational Site 1005
🇺🇸Ocoee, Florida, United States
Investigational Site 1004
🇺🇸Camp Hill, Pennsylvania, United States
Investigational Site 1048
🇺🇸Fort Worth, Texas, United States
Investigational Site 4210
🇦🇺Clayton, Australia
Investigational Site 7143
🇺🇸Rochester, New York, United States
Investigational Site 1080
🇺🇸Jonesboro, Georgia, United States
Investigational Site 1095
🇺🇸Columbus, Georgia, United States
Investigational Site 1047
🇺🇸Fort Worth, Texas, United States
Investigational Site 2001
🇨🇦London, Ontario, Canada
Investigational Site 2903
🇧🇷Curitiba, Brazil
Investigational Site 2904
🇧🇷Sao Bernardo do Campo, Brazil
Investigational Site 4213
🇦🇺Garran, Australia
Investigational Site 2700
🇧🇾Minsk, Belarus
Investigational Site 2901
🇧🇷Curitiba, Brazil
Investigational Site 2910
🇧🇷Sao Paulo, Brazil
Investigational Site 2911
🇧🇷Sao Paulo, Brazil
Investigational Site 1059
🇺🇸Midland, Texas, United States
Investigational Site 1066
🇺🇸Randallstown, Virginia, United States
Investigational Site 4205
🇦🇺Bedford Park, Australia
Investigational Site 1040
🇺🇸New Braunfels, Texas, United States
Investigational Site 1053
🇺🇸Vancouver, Washington, United States
Investigational Site 4206
🇦🇺Saint Leonards NSW, Australia
Investigational Site 4200
🇦🇺Windsor, Australia
Investigational Site 1103
🇦🇷Buenos Aires, Argentina
Investigational Site 1108
🇦🇷Buenos Aires, Argentina
Investigational Site 4319
🇨🇳Nanning, China
Investigational Site 1024
🇺🇸Norfolk, Virginia, United States
Investigational Site 6010
🇩🇰Aarhus, Denmark
Investigational Site 1025
🇺🇸Newport News, Virginia, United States
Investigational Site 1902
🇨🇿Liberec, Czechia
Investigational Site 2905
🇧🇷Belo Horizonte, Brazil
Investigational Site 4207
🇦🇺Perth, Australia
Investigational Site 2004
🇨🇦Montreal, Canada
Investigational Site 2902
🇧🇷Sao Paulo, Brazil
Investigational Site 2005
🇨🇦Halifax, Canada
Investigational Site 4212
🇦🇺Westmead NSW, Australia
Investigational Site 4203
🇦🇺Redcliffe, Australia
Investigational Site 3337
🇫🇷Paris, France
Investigational Site 2802
🇦🇹Feldkirch, Austria
Investigational Site 2000
🇨🇦Ottawa, Ontario, Canada
Investigational Site 2003
🇨🇦Richmond Hill, Ontario, Canada
Investigational Site 4317
🇨🇳Kunming, China
Investigational Site 4303
🇨🇳Shanghai, China
Investigational Site 3314
🇫🇷Agen, France
Investigational Site 1708
🇩🇪Witten, Germany
Investigational Site 3311
🇫🇷Angers, France
Investigational Site 6001
🇩🇰Svendborg, Denmark
Investigational Site 2912
🇧🇷Porto Alegre, Brazil
Investigational Site 3321
🇫🇷Annecy, France
Investigational Site 4209
🇦🇺Box Hill, Australia
Investigational Site 2914
🇧🇷Campinas, Brazil
Investigational Site 2906
🇧🇷Sao Paulo, Brazil
Investigational Site 4327
🇨🇳Beijing, China
Investigational Site 1200
🇨🇱Santiago, Chile
Investigational Site 2102
🇪🇪Tartu, Estonia
Investigational Site 1715
🇩🇪Bruchsal, Germany
Investigational Site 3308
🇫🇷Paris, France
Investigational Site 1707
🇩🇪Dresden, Germany
Investigational Site 4324
🇨🇳Shanghai, China
Investigational Site 3339
🇫🇷Lille, France
Investigational Site 3305
🇫🇷Saint-Etienne Cedex, France
Investigational Site 4320
🇨🇳Tianjin, China
Investigational Site 2900
🇧🇷Sao Paulo, Brazil
Investigational Site 4337
🇨🇳Beijing, China
Investigational Site 3310
🇫🇷Brest, France
Investigational Site 3327
🇫🇷Colombes Cedex, France
Investigational Site 3303
🇫🇷Montpellier, France
Investigational Site 3319
🇫🇷Nice, France
Investigational Site 1901
🇨🇿Plzen, Czechia
Investigational Site 1908
🇨🇿Olomouc, Czechia
Investigational Site 1905
🇨🇿Ostrava, Czechia
Investigational Site 1720
🇩🇪Bielefeld, Germany
Investigational Site 2100
🇪🇪Tallinn, Estonia
Investigational Site 4405
🇮🇳Bangalore, India
Investigational Site 1718
🇩🇪Berlin, Germany
Investigational Site 1721
🇩🇪Hamburg, Germany
Investigational Site 4335
🇨🇳Shanghai, China
Investigational Site 1904
🇨🇿Praha, Czechia
Investigational Site 3333
🇫🇷Cannes, France
Investigational Site 3336
🇫🇷Pierre Benite, France
Investigational Site 5412
🇭🇺Zalaegerszeg, Hungary
Investigational Site 5514
🇮🇳Holon, India
Investigational Site 1719
🇩🇪Dortmund, Germany
Investigational Site 1712
🇩🇪Mainz, Germany
Investigational Site 3301
🇫🇷Besancon Cedex, France
Investigational Site 3329
🇫🇷Bordeaux, France
Investigational Site 5401
🇭🇺Budapest, Hungary
Investigational Site 1711
🇩🇪Paderborn, Germany
Investigational Site 5402
🇭🇺Kecskemet, Hungary
Investigational Site 5414
🇭🇺Budapest, Hungary
Investigational Site 5409
🇭🇺Budapest, Hungary
Investigational Site 4430
🇮🇳Hyderabad, India
Investigational Site 3503
🇮🇹Varese, Italy
Investigational Site 3508
🇮🇹Bergamo, Italy
Investigational Site 3506
🇮🇹Chieti, Italy
Investigational Site 3504
🇮🇹Milano, Italy
Investigational Site 3501
🇮🇹Pavia, Italy
Investigational Site 3510
🇮🇹Udine, Italy
Investigational Site 4428
🇮🇳New Delhi, India
Investigational Site 4509
🇰🇷Daegu, Korea, Republic of
Investigational Site 3507
🇮🇹Parma, Italy
Investigational Site 4438
🇮🇳Pune, India
Investigational Site 5508
🇮🇱Haifa, Israel
Investigational Site 4515
🇰🇷Seoul, Korea, Republic of
Investigational Site 3502
🇮🇹Palermo, Italy
Investigational Site 5513
🇮🇱Nahariya, Israel
Investigational Site 3500
🇮🇹Emilia, Italy
Investigational Site 3505
🇮🇹Rozzano, Italy
Investigational Site 3509
🇮🇹Venezia, Italy
Investigational Site 4501
🇰🇷Gyeonggi-do, Korea, Republic of
Investigational Site 4507
🇰🇷Seoul, Korea, Republic of
Investigational Site 4702
🇳🇿Auckland, New Zealand
Investigational Site 4900
🇿🇦Worcester, South Africa
Investigational Site 1311
🇲🇽Col. Lomas Altas C.P, Mexico
Investigational Site 4103
🇨🇭Aarau, Switzerland
Investigational Site 3900
🇸🇪Hallingsjo, Sweden
Investigational Site 3905
🇸🇪Stockholm, Sweden
Investigational Site 4508
🇰🇷Seoul, Korea, Republic of
Investigational Site 3612
🇳🇱Heerlen, Netherlands
Investigational Site 5005
🇵🇱Krakow, Poland
Investigational Site 3902
🇸🇪Sundsvall, Sweden
Investigational Site 7006
🇬🇧Hull, United Kingdom
Investigational Site 4704
🇳🇿Wellington, New Zealand
Investigational Site 3609
🇳🇱Assen, Netherlands
Investigational Site 5203
🇹🇭Nakhorn Nayok, Thailand
Investigational Site 3903
🇸🇪Stockholm, Sweden
Investigational Site 5702
🇹🇷Istanbul, Turkey
Investigational Site 4904
🇿🇦Somerset West, South Africa
Investigational Site 4110
🇨🇭Basel, Switzerland
Investigational site 1503
🇪🇸Barcelona, Spain
Investigational Site 4104
🇨🇭Bellinzona, Switzerland
Investigational Site 4010
🇺🇦Donetsk, Ukraine
Investigational Site 5706
🇹🇷Istanbul, Turkey
Investigational Site 5103
🇨🇳Taipei, Taiwan
Investigational Site 7003
🇬🇧London, United Kingdom
Investigational Site 3904
🇸🇪Kristianstad, Sweden
Investigational Site 5703
🇹🇷Ankara, Turkey
Investigational Site 1502
🇪🇸Cabra, Spain
Investigational Site 4109
🇨🇭Lausanne, Switzerland
Investigational Site 4002
🇺🇦Kharkiv, Ukraine
Investigational Site 4007
🇺🇦Ternopil, Ukraine
Investigational Site 4006
🇺🇦Zaporizhzhia, Ukraine
Investigational Site 7005
🇬🇧Coventry, United Kingdom
Investigational Site 7007
🇬🇧Plymouth, United Kingdom
Investigational Site 7004
🇬🇧London, United Kingdom
Investigational Site 7000
🇬🇧London, United Kingdom
Investigational Site 1070
🇺🇸Anaheim, California, United States
Investigational Site 1071
🇺🇸Clearwater, Florida, United States
Investigational Site 7117
🇺🇸Fort Myers, Florida, United States
Investigational Site 7144
🇺🇸Sarasota, Florida, United States
Investigational Site 1007
🇺🇸Winter Park, Florida, United States
Investigational Site 7146
🇺🇸Savannah, Georgia, United States
Investigational Site 1098
🇺🇸Park Ridge, Illinois, United States
Investigational Site 7115
🇺🇸Paducah, Kentucky, United States
Investigational Site 1068
🇺🇸Baltimore, Maryland, United States
Investigational Site 7147
🇺🇸Butte, Montana, United States
Investigational Site 7145
🇺🇸Statesville, North Carolina, United States
Investigational Site 7138
🇺🇸Maumee, Ohio, United States
Investigational Site 1049
🇺🇸Kingston, Pennsylvania, United States
Investigational Site 1036
🇺🇸Spartanburg, South Carolina, United States
Investigational Site 1009
🇺🇸Arlington, Texas, United States
Investigational Site 1050
🇺🇸Dallas, Texas, United States
Investigational Site 1003
🇺🇸Fredericksburg, Virginia, United States
Investigational Site 1030
🇺🇸Virginia Beach, Virginia, United States
Investigational Site 7120
🇺🇸Seattle, Washington, United States
Investigational Site 2007
🇨🇦Newmarket, Ontario, Canada
Investigational Site 1039
🇺🇸Las Vegas, Nevada, United States
Investigational Site 4321
🇨🇳Beijing, China
Investigational Site 4316
🇨🇳Guangzhou, China
Investigational Site 4310
🇨🇳Hangzhou, China
Investigational Site 4313
🇨🇳Qingdao, China
Investigational Site 4330
🇨🇳Shanghai, China
Investigational Site 4326
🇨🇳Shenyang, China
Investigational Site 4308
🇨🇳Sichuan Province, China
Investigational Site 4318
🇨🇳Taiyuan, China
Investigational site 4338
🇨🇳Xi'an, China
Investigational Site 4315
🇨🇳Yinchuan, China
Investigational Site 7123
🇺🇸Salt Lake City, Utah, United States
Investigational Site 7135
🇺🇸Durham, North Carolina, United States
Investigational Site 1002
🇺🇸San Antonio, Texas, United States
Investigational Site 6003
🇩🇰Herlev, Denmark
Investigational Site 3323
🇫🇷Dijon, France
Investigational Site 3307
🇫🇷Grenoble, France
Investigational Site 3322
🇫🇷Grenoble, France
Investigational Site 3325
🇫🇷Hetztessy, France
Investigational Site 3328
🇫🇷Le Mans, France
Investigational Site 3313
🇫🇷Paris, France
Investigational Site 3335
🇫🇷Pessac, France
Investigational Site 3341
🇫🇷Pessac, France
Investigational Site 3316
🇫🇷Toulon, France
Investigational Site 7126
🇺🇸Phoenix, Arizona, United States
Investigational Site 1017
🇺🇸Denver, Colorado, United States
Investigational Site 1704
🇩🇪Munchen, Germany
Investigational Site 1714
🇩🇪Nordhausen, Germany
Investigational Site 1910
🇨🇿Plzen, Czechia
Investigational Site 7103
🇺🇸Mobile, Alabama, United States
Investigational Site 7139
🇺🇸Little Rock, Arkansas, United States
Investigational Site 1093
🇺🇸Monterey, California, United States
Investigational Site 7125
🇺🇸Los Alamitos, California, United States
Investigational Site 7150
🇺🇸San Diego, California, United States
Investigational Site 1089
🇺🇸Vista, California, United States
Investigational Site 1012
🇺🇸Aurora, Colorado, United States
Investigational Site 1013
🇺🇸Boulder, Colorado, United States
Investigational Site 1018
🇺🇸Lakewood, Colorado, United States
Investigational Site 1019
🇺🇸Littleton, Colorado, United States
Investigational Site 1022
🇺🇸Thornton, Colorado, United States
Investigational Site 1023
🇺🇸Thornton, Colorado, United States
Investigational Site 1031
🇺🇸Easley, South Carolina, United States
Investigational Site 1033
🇺🇸Greenville, South Carolina, United States
Investigational Site 1035
🇺🇸Seneca, South Carolina, United States
Investigational Site 1058
🇺🇸Sugar Land, Texas, United States
Investigational Site 4211
🇦🇺Fremantle, Australia
Investigational Site 4214
🇦🇺South Brisbane, Australia
Investigational Site 2915
🇧🇷Porto Alegre, Brazil
Investigational Site 2917
🇧🇷Porto Alegre, Brazil
Investigational Site 1204
🇨🇱Santiago, Chile
Investigational Site 4306
🇨🇳Beijing, China
Investigational Site 4325
🇨🇳Jiangsu, China
Investigational Site 3318
🇫🇷Lyon, France
Investigational Site 1700
🇩🇪Darmstadt, Germany
Investigational Site 1701
🇩🇪Dresden, Germany
Investigational Site 5405
🇭🇺Kistarcsa, Hungary
Investigational Site 5403
🇭🇺Szentes, Hungary
Investigational Site 5408
🇭🇺Szombathely, Hungary
Investigational Site 5400
🇭🇺Debrecen, Hungary
Investigational Site 4460
🇮🇳Bangalore, India
Investigational Site 6146
🇯🇵Nagano, Japan
Investigational Site 6135
🇯🇵Okinawa, Japan
Investigational Site 4513
🇰🇷Busan, Korea, Republic of
Investigational Site 1312
🇲🇽Guadalajara, Mexico
Investigational Site 1305
🇲🇽Monterrey, Nuevo Leon, Mexico
Investigational Site 1308
🇲🇽San Luis Potosi, Mexico
Investigational Site 1301
🇲🇽Yucatan, Mexico
Investigational Site 3607
🇳🇱Almere, Netherlands
Investigational Site 3617
🇳🇱Amersfoort, Netherlands
Investigational Site 3611
🇳🇱Amsterdam, Netherlands
Investigational Site 3613
🇳🇱Hoofddorp, Netherlands
Investigational Site 3603
🇳🇱Groningen, Netherlands
Investigational Site 3615
🇳🇱Rotterdam, Netherlands
Investigational Site 4703
🇳🇿Auckland, New Zealand
Investigational Site 4700
🇳🇿Christchurch, New Zealand
Investigational Site 3701
🇳🇴Fredrikstad, Norway
Investigational Site 3700
🇳🇴Oslo, Norway
Investigational Site 4800
🇵🇭Quezon City, Philippines
Investigational site 4801
🇵🇭Quezon City, Philippines
Investigational Site 4802
🇵🇭Quezon City, Philippines
Investigational Site 5015
🇵🇱Bialystok, Poland
Investigational Site 5019
🇵🇱Olsztyn, Poland
Investigational Site 5003
🇵🇱Warszawa, Poland
Investigational Site 5007
🇵🇱Warszawa, Poland
Investigational Site 5008
🇵🇱Warszawa, Poland
Investigational Site 5014
🇵🇱Warszawa, Poland
Investigational Site 3023
🇷🇺Chelyabinsk, Russian Federation
Investigational Site 3017
🇷🇺Irkutsk, Russian Federation
Investigational Site 3019
🇷🇺Kemerovo, Russian Federation
Investigational Site 3020
🇷🇺Krasnoyarsk, Russian Federation
Investigational Site 3030
🇷🇺Krasnoyarsk, Russian Federation
Investigational Site 3029
🇷🇺Moscow, Russian Federation
Investigational Site 3028
🇷🇺Novosibirsk, Russian Federation
Investigational Site 3009
🇷🇺Omsk, Russian Federation
Investigational Site 3022
🇷🇺Ryazan, Russian Federation
Investigational Site 3024
🇷🇺Sochi, Russian Federation
Investigational Site 3027
🇷🇺St. Petersburg, Russian Federation
Investigational Site 3000
🇷🇺St. Petersburg, Russian Federation
Investigational Site 3003
🇷🇺St. Petersburg, Russian Federation
Investigational Site 3025
🇷🇺Tyumen, Russian Federation
Investigational Site 3016
🇷🇺Ufa, Russian Federation
Investigational Site 3010
🇷🇺Yaroslavl, Russian Federation
Investigational Site 3004
🇷🇺Yaroslavl, Russian Federation
Investigational Site 1069
🇺🇸Palm Springs, California, United States
Investigational Site 5900
🇸🇬Outram Road, Singapore
Investigational Site 5902
🇸🇬Singapore, Singapore
Investigational Site 4912
🇿🇦Cape Town, South Africa
Investigational Site 4907
🇿🇦Centurion, South Africa
Investigational Site 4901
🇿🇦Johannesburg, South Africa
Investigational Site 4910
🇿🇦Johannesburg, South Africa
Investigational Site 4909
🇿🇦Johannesburg, South Africa
Investigational Site 4905
🇿🇦Johannesburg, South Africa
Investigational Site 4908
🇿🇦Lyttleton, South Africa
Investigational Site 4903
🇿🇦Pretoria, South Africa
Investigational Site 4906
🇿🇦Pretoria, South Africa
Investigational Site 4102
🇨🇭Chur, Switzerland
Investigational Site 7001
🇬🇧Newcastle, United Kingdom
Investigational Site 1056
🇺🇸Vancouver, Washington, United States
Investigational Site 1057
🇺🇸Vancouver, Washington, United States
Investigational Site 4301
🇨🇳Beijing, China
Investigational Site 4302
🇨🇳Beijing, China
Investigational Site 3312
🇫🇷Paris, France
Investigational Site 5404
🇭🇺Budapest, Hungary
Investigational Site 7132
🇺🇸Montgomery, Alabama, United States
Investigational Site 7128
🇺🇸Uniontown, Pennsylvania, United States
Investigational Site 4506
🇰🇷Seoul, Korea, Republic of
Investigational Site 1006
🇺🇸Orlando, Florida, United States
Investigational Site 7133
🇺🇸Kansas City, Missouri, United States
Investigational Site 7154
🇺🇸Sellersville, Pennsylvania, United States
Investigational Site 1041
🇺🇸Odessa, Texas, United States
Investigational Site 1008
🇺🇸Waco, Texas, United States
Investigational Site 4328
🇨🇳Nanjing, China