Ultrasound-guided Thermal Ablation for Recurrent Thyroid Cancer

Recruiting

• Conditions: Recurrent Thyroid Cancer

• Registration Number: NCT06733766
• Lead Sponsor: Chinese PLA General Hospital

Brief Summary

To evaluate the long-term outcomes of ultrasound-guided thermal ablation for recurrent thyroid cancer

Detailed Description

To evaluate and predict the long-term outcomes of ultrasound-guided thermal ablation for recurrent thyroid cancer by a multicenter study

Study Timeline

• Study First Submitted: 2024-12-07
• Study Start: 2024-12-09
• Study First Submitted QC: 2024-12-12
• Study First Posted: 2024-12-13
• Status Verified: 2025-02
• Last Update Submitted: 2025-02-13
• Last Update Posted: 2025-03-25
• Primary Completion: 2028-12-31
• Study Completion: 2030-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

1. patient received thyroidectomy for thyroid cancer
2. recurrent lesions were pathologically proven to be malignant by core-needle biopsy or fine needle aspiration
3. no evidence of distant metastases.
4. follow-up period ≥12 months

Exclusion Criteria

1. coagulation disorder, serious heart, respiratory, liver, or renal failure
2. dysfunction of the vocal cord on the opposite side

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
rate of disease progression	through study completion, an average of 6 months	cervical lymph node metastases and persistent tumors confirmed by pathology, Distant metastasis detected by CT, positron emission tomography, or bone scan if there were suspicious symptoms.

Secondary Outcome Measures

Name	Time	Method
rate of complications	1 week	complication of ablation
rate of volume reduction	through study completion, an average of 6 months	volume reduction of tumor after ablation on ultrasound and contrast-enhanced ultrasound
rate of tumor disappearance	through study completion, an average of 6 months	complete disappearance of ablated tumor on ultrasound and contrast-enhanced ultrasound
Tg level	through study completion, an average of 6 months	serum thyroglobulin level
rate of delayed surgery	through study completion, an average of 1 year	patients underwent surgery after ablation because of anxiety

Trial Locations

Locations (1)

Chinese PLA General Hospital; 🇨🇳 Beijing, Beijing, China